Xenobiotic Sensor- and Metabolism-Related Gene Variants in Environmental Sensitivity-Related Illnesses: A Survey on the Italian Population
Table 1
Allele and genotype frequencies of some drug metabolism-related gene variants in SRI patients (MCS: multiple chemical sensitivity; sMCS: suspected multiple chemical sensitivity; FM/CFS: fibromyalgia/chronic fatigue syndrome) and healthy subjects (Ctr: controls).
Genotype
MCS
SMCS
FM/CFS
Ctr
CYP2C9
= 101
= 94
= 80
= 90
Wt
66.3%
66%
55%
84.4%
Ht*1/*2
23.8%†
18.1%
15%
12.2%
Ht*1/*3
6.9%
11.7%††
20%††††
1.1%
PM*2/*2
0.9%
2.1%
3.75%
2.2%
PM*2/*3
0.9%
—
2.5%
—
PM*3/*3
0.9%
2.1%
3.75%
—
*
2 allele frequency
0.13
0.11
0.125†
0.083
*
3 allele frequency
0.048††
0.079†††
0.15††††
0.007
CYP2C19
= 101
= 93
= 80
= 62
Wt
61.4%
84.8%
78.8%
80.3%
Ht*1/*2
36.6
14.1%
20.0%
16.7%
PM*2/*2
2.0%
1.1%
1.3%
3.0%
*
2 allele frequency
0.20
0.081
0.113
0.113
CYP2D6
= 55
= 93
= 75
= 113
Wt
40%
52.7%
40.7%
77.9%
Ht*1/*4
36.4%††
25.8%†
28.5%†
18.6%
Ht*1/*41
14.8%††††
5.4%††††
7.4%††††
—
PM*4/*4
5.5%
4.3%
8.5%
3.5%
PM*4/*41
3.6%
7.5%
7.4%
—
PM*41/*41
—
4.3%
7.4%
—
*
4 allele frequency
0.255†††
0.209††
0.314††††
0.128
*
41 allele frequency
0.092††††
0.107††††
0.148††††
—
< 0.05 versus Ctr, †† < 0.01 versus Ctr; ††† < 0.001 versus Ctr, †††† < 0.0001 versus Ctr; < 0.05 versus FM/CFS; < 0.01 versus FM/CFS; # < 0.05 versus SMCS; ## < 0.01 versus SMCS; ### < 0.001 versus SMCS.