The Triggering Receptor Expressed on Myeloid Cells 2: “TREM-ming” the Inflammatory Component Associated with Alzheimer's Disease
Figure 1
The microscopic trouble makers in Alzheimer’s disease: senile plaques and neurofibrillary tangles. (a) In AD, widespread accumulation of extracellular beta-amyloid plaques is evident (arrowhead), together with the presence of an abundance of NFTs along with neuropil threads, which are composed principally of modified and aggregated tau (arrow). (b) For comparison purposes, an age-matched control brain is depicted indicating a complete absence of plaques. However, it is not uncommon to find an occasional tangle (arrow) in the normally aged brain although the numbers of tangles is minimal by comparison. Brain sections are representative staining of the hippocampus using an anti-beta-amyloid antibody to label plaques (brown) and anti-PHF-1 (black) to label NFTs. Scale bars are 10 μm.
