Oxidative Medicine and Cellular Longevity / 2013 / Article / Tab 1

Review Article

ROS and Brain Diseases: The Good, the Bad, and the Ugly

Table 1

Drugs with anti-inflammatory and antioxidant effects currently under investigation for the treatment of several neuropsychiatric diseases.

DrugBrain diseaseMechanismReference

-3 PUFAADHDNonspecific antioxidant effect[151, 152]
Vitamin CVascular dementiaFree radical scavenger[153]
Hyperbaric O2AutismAnti-inflammatory and reduces oxidative stress[157]
H2SFocal cerebral ischemia/reperfusionInhibits oxidative phosphorylation, inflammation, and apoptosis[159]
H2-rich salineFocal or global cerebral ischemia/reperfusionReduces oxidative stress and inflammation[160, 161]
LithiumHealthy volunteersPrevents/or reverses DNA damage, lipid peroxidation, and free radical formation[164]
Pifithrin- Perinatal hypoxic-ischemic brain damageInhibition of the apoptotic pathways and reduction of the oxidative stress[166]
TelmisartanVascular dementiaAnti-inflammatory and antioxidant effects[174176]
NanodrugsROS scavengers[177]
TriterpenoidsParkinsonAntioxidants via Nrf2/ARE pathway[146]
PPARgamma agonistsNeurodegenerative diseasesAnti-inflammatory[162164]