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Oxidative Medicine and Cellular Longevity
Volume 2013, Article ID 972913, 10 pages
http://dx.doi.org/10.1155/2013/972913
Review Article

Role of Glutathione in Cancer Progression and Chemoresistance

Department of Experimental Medicine, Section of General Pathology, Via LB Alberti 2, 16132 Genoa, Italy

Received 22 January 2013; Revised 26 April 2013; Accepted 29 April 2013

Academic Editor: Donald A. Vessey

Copyright © 2013 Nicola Traverso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Baez-Villalobos Edwin, Siles-Canales Francisco, and Mora-Rodriguez Ra, “A biocomputational application for the automated construction of large-scale metabolic models from transcriptomic data,” 2016 IEEE 36th Central American and Panama Convention (CONCAPAN XXXVI), pp. 1–6, . View at Publisher · View at Google Scholar
  • Avishek Ganguly, Paramita Chakraborty, Kaushik Banerjee, and Soumitra Kumar Chaudhuri, “The role of a Schiff base scaffold, N-(2-hydroxy acetophenone) glycinate-in overcoming multidrug resistance in cancer,” European Journal of Pharmaceutical Sciences, 2013. View at Publisher · View at Google Scholar
  • Varsha Singh, and Rupali Panwar, “In vivo antioxidative and neuroprotective effect of 4-Allyl-2-methoxyphenol against chlorpyrifos-induced neurotoxicity in rat brain,” Molecular and Cellular Biochemistry, 2013. View at Publisher · View at Google Scholar
  • Shanmugasundaram Ganapathy-Kanniappan, and Jean-Francois H. Geschwind, “Tumor glycolysis as a target for cancer therapy: Progress and prospects,” Molecular Cancer, vol. 12, no. 1, 2013. View at Publisher · View at Google Scholar
  • Anna Kakehashi, Min Wei, Shoji Fukushima, and Hideki Wanibuchi, “Oxidative Stress in the Carcinogenicity of Chemical Carcinogens,” Cancers, vol. 5, no. 4, pp. 1332–1354, 2013. View at Publisher · View at Google Scholar
  • Reza Hakkak, Soheila Korourian, and Stepan Melnyk, “Obesity, oxidative stress and breast cancer risk,” Journal of Cancer Science and Therapy, vol. 5, no. 12, 2013. View at Publisher · View at Google Scholar
  • Barak Rotblat, Thomas G.P. Grunewald, Gerry Melino, Gabriel Leprivier, and Richard A. Knight, “Anti-oxidative stress response genes: Bioinformatic analysis of their expression and relevance in multiple cancers,” Oncotarget, vol. 4, no. 12, pp. 2577–2590, 2013. View at Publisher · View at Google Scholar
  • Xiaozhe Qi, Tao Yu, Liye Zhu, Jing Gao, Xiaoyun He, Kunlun Huang, Yunbo Luo, and Wentao Xu, “Ochratoxin A induces rat renal carcinogenicity with limited induction of oxidative stress responses,” Toxicology and Applied Pharmacology, 2014. View at Publisher · View at Google Scholar
  • Patricia T. Lee, Denise Lowinsohn, and Richard G. Compton, “Electrocatalytic detection of glutathione - The search for new mediators,” Journal of the Brazilian Chemical Society, vol. 25, no. 9, pp. 1614–1620, 2014. View at Publisher · View at Google Scholar
  • Shinya Toyokuni, “Iron and thiols as two major players in carcinogenesis: friends or foes?,” Frontiers in Pharmacology, vol. 5, 2014. View at Publisher · View at Google Scholar
  • Philip J Blower, Richard Siow, Richard Southworth, Fiona Shaughnessy, Erika Mariotti, Karen P Shaw, and Thomas R Eykyn, “Modification of intracellular glutathione status does not change the cardiac trapping of 64Cu(ATSM),” EJNMMI Research, vol. 4, no. 1, 2014. View at Publisher · View at Google Scholar
  • Dong-Xu He, Yu-Dong Xia, Xiao-Ting Gu, Jian Jin, and Xin Ma, “A 20-gene signature in predicting the chemoresistance of breast cancer to taxane-based chemotherapy,” Mol. BioSyst., vol. 10, no. 12, pp. 3111–3119, 2014. View at Publisher · View at Google Scholar
  • M. Leticia Castro, Melanie J. McConnell, and Patries M. Herst, “Radio-sensitisation by pharmacological ascorbate in glioblastoma multiforme cells, Human glial cells and HUVECs depends on their antioxidant and DNA repair capabilities and Is not Cancer specific,” Free Radical Biology and Medicine, 2014. View at Publisher · View at Google Scholar
  • Doriane Lorendeau, Lauriane Dury, Estelle Genoux-Bastide, Florine Lecerf-Schmidt, Claudia Simões-Pires, Pierre-Alain Carrupt, Raphaël Terreux, Sandrine Magnard, Attilio Di Pietro, Ahcène Boumendjel, and Hélène Baubichon-Cortay, “Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux,” Biochemical Pharmacology, 2014. View at Publisher · View at Google Scholar
  • Oranuch Nakchat, Nonthaneth Nalinratana, Duangdeun Meksuriyen, and Sunanta Pongsamart, “Tamarind seed coat extract restores reactive oxygen species through attenuation of glutathione level and antioxidant enzyme expression in human skin fibroblasts in response to oxidative stress,” Asian Pacific Journal of Tropical Biomedicine, vol. 4, no. 5, pp. 379–385, 2014. View at Publisher · View at Google Scholar
  • Valery V. Khramtsov, and Robert J. Gillies, “Janus-Faced Tumor Microenvironment and Redox,” Antioxidants & Redox Signaling, pp. 140304070544006, 2014. View at Publisher · View at Google Scholar
  • Seong-Wook Yun, Nam-Young Kang, Sung-Jin Park, Hyung-Ho Ha, Yun Kyung Kim, Jun-Seok Lee, and Young-Tae Chang, “Diversity Oriented Fluorescence Library Approach (DOFLA) for Live Cell Imaging Probe Development,” Accounts of Chemical Research, pp. 140219155116009, 2014. View at Publisher · View at Google Scholar
  • Mark Noble, Margot Mayer-Pröschel, Zaibo Li, Tiefei Dong, Wanchang Cui, Christoph Pröschel, Ibro Ambeskovic, Joerg Dietrich, Ruolan Han, Yin Miranda Yang, Christopher Folts, Jennifer Stripay, Hsing-Yu Chen, and Brett M. Stevens, “Redox biology in normal cells and cancer: Restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment,” Free Radical Biology and Medicine, 2014. View at Publisher · View at Google Scholar
  • Suresh M. Chopade, Prasad P. Phadnis, Ananda S. Hodage, Amey Wadawale, and Vimal K. Jain, “Synthesis, characterization, structures and cytotoxicity of platinum(II) complexes containing dimethylpyrazole based selenium ligands,” Inorganica Chimica Acta, 2014. View at Publisher · View at Google Scholar
  • Kelley Salem, Michael L. McCormick, Erik Wendlandt, Fenghuang Zhan, and Apollina Goel, “Copper–zinc superoxide dismutase-mediated redox regulation of bortezomib resistance in multiple myeloma,” Redox Biology, 2014. View at Publisher · View at Google Scholar
  • Ralf Dringen, Maria Brandmann, Michaela C. Hohnholt, and Eva-Maria Blumrich, “Glutathione-Dependent Detoxification Processes in Astrocytes,” Neurochemical Research, 2014. View at Publisher · View at Google Scholar
  • Qiang Yang, Haihua Xiao, Jing Cai, Zhigang Xie, Zehua Wang, and Xiabin Jing, “Nanoparticle mediated delivery of a GST inhibitor ethacrynic acid for sensitizing platinum based chemotherapy,” RSC Adv., vol. 4, no. 105, pp. 61124–61132, 2014. View at Publisher · View at Google Scholar
  • Cláudia M. Rocha, António S. Barros, Brian J. Goodfellow, Isabel M. Carreira, Ana Gomes, Vitor Sousa, João Bernardo, Lina Carvalho, Ana M. Gil, and Iola F. Duarte, “NMR metabolomics of human lung tumours reveals distinct metabolic signatures for adenocarcinoma and squamous cell carcinoma,” Carcinogenesis, vol. 36, no. 1, pp. 68–75, 2014. View at Publisher · View at Google Scholar
  • Zbynek Heger, Jaromir Gumulec, Natalia Cernei, Katerina Tmejova, Pavel Kopel, Jan Balvan, Michal Masarik, Ondrej Zitka, Miroslava Beklova, Vojtech Adam, and Rene Kizek, “17β-estradiol-containing liposomes as a novel delivery system for the antisense therapy of ER-positive breast cancer: An in�vitro study on the MCF-7 cell line,” Oncology Reports, 2014. View at Publisher · View at Google Scholar
  • Duan Chen, Andrey A. Bobko, Amy C. Gross, Randall Evans, Clay B. Marsh, Valery V. Khramtsov, Timothy D. Eubank, and Avner Friedman, “Involvement of Tumor Macrophage HIFs in Chemotherapy Effectiveness: Mathematical Modeling of Oxygen, pH, and Glutathione,” Plos One, vol. 9, no. 10, 2014. View at Publisher · View at Google Scholar
  • Azeddine Bentaib, Pascal De Tullio, Hervé Chneiweiss, Emmanuel Hermans, Marie-Pierre Junier, and Pierre Leprince, “Metabolic reprogramming in transformed mouse cortical astrocytes: A proteomic study,” Journal of Proteomics, 2014. View at Publisher · View at Google Scholar
  • Yilin Liu, Annastasia S. Hyde, Melanie A. Simpson, and Joseph J. Barycki, “Emerging Regulatory Paradigms in Glutathione Metabolism,” Redox and Cancer Part A, vol. 122, pp. 69–101, 2014. View at Publisher · View at Google Scholar
  • Marie H. Hanigan, “Gamma-Glutamyl Transpeptidase,” Redox and Cancer Part A, vol. 122, pp. 103–141, 2014. View at Publisher · View at Google Scholar
  • Jolie Kiemlian Kwee, “A Paradoxical Chemoresistance and Tumor Suppressive Role of Antioxidant in Solid Cancer Cells: A Strange Case of Dr. Jekyll and Mr. Hyde,” BioMed Research International, vol. 2014, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • Dibyendu Talukdar, and Tulika Talukdar, “Leaf Rolling and Stem Fasciation in Grass Pea (Lathyrus sativus L.) Mutant Are Mediated through Glutathione-Dependent Cellular and Metabolic Changes and Associated with a Metabolic Diversion through Cysteine during Phenotypic Reversal,” BioMed Research International, vol. 2014, pp. 1–21, 2014. View at Publisher · View at Google Scholar
  • Marianna Cerasuolo, Debora Paris, Fabio A. Iannotti, Dominique Melck, Roberta Verde, Enrico Mazzarella, Andrea Motta, and Alessia Ligresti, “Neuroendocrine transdifferentiation in human prostate cancer cells: An integrated approach,” Cancer Research, vol. 75, no. 15, pp. 2975–2986, 2015. View at Publisher · View at Google Scholar
  • Manuela Curcio, Barbara Blanco-Fernandez, Luis Diaz-Gomez, Angel Concheiro, and Carmen Alvarez-Lorenzo, “Hydrophobically Modified Keratin Vesicles for GSH-Responsive Intracellular Drug Release,” Bioconjugate Chemistry, pp. 150826084432005, 2015. View at Publisher · View at Google Scholar
  • Haiquan Lu, Debangshu Samanta, Lisha Xiang, Huimin Zhang, Hongxia Hu, Ivan Chen, John W. Bullen, and Gregg L. Semenza, “Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype,” Proceedings of the National Academy of Sciences, vol. 112, no. 33, pp. E4600–E4609, 2015. View at Publisher · View at Google Scholar
  • Ru-Ming Liu, Xiao-Jie Zhang, Gui-You Liang, Yong-Fu Yang, Jian-Jiang Zhong, and Jian-Hui Xiao, “Antitumor and antimetastatic activities of chloroform extract of medicinal mushroom Cordyceps taii in mouse models,” BMC Complementary and Alternative Medicine, vol. 15, no. 1, 2015. View at Publisher · View at Google Scholar
  • Dmitri Rozanov, Anton Cheltsov, Eduard Sergienko, Stefan Vasile, Vladislav Golubkov, Alexander E. Aleshin, Trevor Levin, Elie Traer, Byron Hann, Julia Freimuth, Nikita Alexeev, Max A. Alekseyev, Sergey P. Budko, Hans Peter Baechinger, and Paul Spellman, “TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress R,” Plos One, vol. 10, no. 6, 2015. View at Publisher · View at Google Scholar
  • N Mohell, J Alfredsson, Å Fransson, M Uustalu, S Byström, J Gullbo, A Hallberg, V J N Bykov, U Björklund, and K G Wiman, “APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells,” Cell Death and Disease, vol. 6, no. 6, pp. e1794, 2015. View at Publisher · View at Google Scholar
  • Manuela Curcio, Bárbara Blanco-Fernández, Alejandro Costoya, Angel Concheiro, Francesco Puoci, and Carmen Alvarez-Lorenzo, “Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 93, pp. 281–292, 2015. View at Publisher · View at Google Scholar
  • Michael D. Williams, Xing Zhang, Jeong-Jin Park, William F. Siems, David R. Gang, Linda M. S. Resar, Raymond Reeves, and Herbert H. Hill, “Characterizing metabolic changes in human colorectal cancer,” Analytical and Bioanalytical Chemistry, 2015. View at Publisher · View at Google Scholar
  • Anett Patzschke, Matthias G. Steiger, Caterina Holz, Christine Lang, Diethard Mattanovich, and Michael Sauer, “ Enhanced glutathione production by evolutionary engineering of Saccharomyces cerevisiae strains ,” Biotechnology Journal, 2015. View at Publisher · View at Google Scholar
  • Sandeep Kumar Dash, Sourav Chattopadhyay, Totan Ghosh, Shib Shankar Dash, Satyajit Tripathy, Balaram Das, Braja Gopal Bag, Debasis Das, and Somenath Roy, “Self-assembled betulinic acid protects doxorubicin induced apoptosis followed by reduction of ROS–TNF-α–caspase-3 activity,” Biomedicine & Pharmacotherapy, 2015. View at Publisher · View at Google Scholar
  • Qing-Bin Lu, Qin-Rong Zhang, Ning Ou, Chun-Rong Wang, and Jenny Warrington, “In vitro and in vivo Studies of Non-Platinum-Based Halogenated Compounds as a New Class of Potent Antitumor Agents for Natural Targeted Chemotherapy of Cancers,” EBioMedicine, 2015. View at Publisher · View at Google Scholar
  • Helena Joyce, Andrew McCann, Martin Clynes, and Annemarie Larkin, “Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism,” Expert Opinion on Drug Metabolism & Toxicology, pp. 1–15, 2015. View at Publisher · View at Google Scholar
  • Laila M Poisson, Adnan Munkarah, Hala Madi, Indrani Datta, Sharon Hensley-Alford, Calvin Tebbe, Thomas Buekers, Shailendra Giri, and Ramandeep Rattan, “A metabolomic approach to identifying platinum resistance in ovarian cancer,” Journal of Ovarian Research, vol. 8, no. 1, 2015. View at Publisher · View at Google Scholar
  • Eugene Jansen, Piet Beekhof, Abdonas Tamosiunas, Dalia Luksiene, and Migle Baceviciene, “Biomarkers of oxidative stress and redox status in a short-term low-dosed multivitamin and mineral supplementation study in two human age groups,” Biogerontology, vol. 16, no. 5, pp. 645–653, 2015. View at Publisher · View at Google Scholar
  • Rajdeep Chowdhury, Md. Asif Amin, and Kankan Bhattacharyya, “Intermittent Fluorescence Oscillations in Lipid Droplets in a Live Normal and Lung Cancer Cell: Time-Resolved Confocal Microscopy,” The Journal of Physical Chemistry B, pp. 150223133832007, 2015. View at Publisher · View at Google Scholar
  • Stephen John Ralph, Rhys Pritchard, Sara Rodríguez-Enríquez, Rafael Moreno-Sánchez, and Raymond Keith Ralph, “Hitting the bull’s-eye in metastatic cancers—NSAIDs elevate ROS in Mitochondria, inducing malignant cell death,” Pharmaceuticals, vol. 8, no. 1, pp. 62–106, 2015. View at Publisher · View at Google Scholar
  • A A Mahbub, C L Le Maitre, S L Haywood-Small, N A Cross, and N Jordan-Mahy, “Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines,” Cell Death and Disease, vol. 6, no. 12, pp. e2028, 2015. View at Publisher · View at Google Scholar
  • Beverley M. Dancy, Nicole Brockway, Renjini Ramadasan-Nair, Yoing Yang, Margaret M. Sedensky, and Philip G. Morgan, “Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction,” Mechanisms of Ageing and Development, 2015. View at Publisher · View at Google Scholar
  • Bratko Filipič, Lidija Gradišnik, Eugen Šooš, Adriana Pereyra, Jana Potokar, and Klemen Rihar, “The influence of royal jelly and human interferon-alpha (HuIFN-αN3) on proliferation, glutathione level and lipid peroxidation in human colorectal adenocarcinoma cells in vitro,” Arhiv za Higijenu Rada i Toksikologiju, vol. 66, no. 4, pp. 269–274, 2015. View at Publisher · View at Google Scholar
  • Bratko Filipic, Lidija Gradisnik, Klemen Rihar, Eugen Soos, Adriana Pereyra, and Jana Potokar, “The influence of royal jelly and human interferon-alpha (HuIFN-alpha N3) on proliferation, glutathione level and lipid peroxidation in human colorecta,” Arhiv Za Higijenu Rada I Toksikologiju-Archives Of Industrial Hygiene And Toxicology, vol. 66, no. 4, pp. 269–274, 2015. View at Publisher · View at Google Scholar
  • Joe Antony Jacob, and Achiraman Shanmugam, “Silver nanoparticles provoke apoptosis of Dalton's ascites lymphoma in vivo by mitochondria dependent and independent pathways,” Colloids and Surfaces B: Biointerfaces, 2015. View at Publisher · View at Google Scholar
  • Ryuta Tobe, Bradley Carlson, Petra Tsuji, Byeong Lee, Vadim Gladyshev, and Dolph Hatfield, “Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy,” Cancers, vol. 7, no. 4, pp. 2262–2276, 2015. View at Publisher · View at Google Scholar
  • Valeria Sorrenti, Luca Vanella, Rosaria Acquaviva, Venera Cardile, Salvatore Giofre, and Claudia Di Giacomo, “Cyanidin induces apoptosis and differentiation in prostate cancer cells,” International Journal Of Oncology, vol. 47, no. 4, pp. 1303–1310, 2015. View at Publisher · View at Google Scholar
  • Lucas N. Solano, Grady L. Nelson, Conor T. Ronayne, Erica A. Lueth, Melissa A. Foxley, Sravan K. Jonnalagadda, Shirisha Gurrapu, and Venkatram R. Mereddy, “Synthesis, in vitro, and in vivo evaluation of novel functionalized quaternary ammonium curcuminoids as potential anti-cancer agents,” Bioorganic & Medicinal Chemistry Letters, 2015. View at Publisher · View at Google Scholar
  • Taotao Ling, Victor Hadi, Armand Guiguemde, Scott M. Landfear, and Fatima Rivasvol. 45, pp. 77–98, 2015. View at Publisher · View at Google Scholar
  • Vimal Pandey, Vasantha Kumar Bhaskara, and Phanithi Prakash Babu, “Implications of mitogen-activated protein kinase signaling in glioma,” Journal of Neuroscience Research, 2015. View at Publisher · View at Google Scholar
  • Shanmugasundaram Ganapathy-Kanniappanpp. 331–344, 2015. View at Publisher · View at Google Scholar
  • Irene L. Ibañez, Cintia Notcovich, Paolo N. Catalano, Martín G. Bellino, and Hebe Durán, “The redox-active nanomaterial toolbox for cancer therapy,” Cancer Letters, 2015. View at Publisher · View at Google Scholar
  • Rosalia Maria Cigala, Concetta De Stefano, Anna Irto, Demetrio Milea, and Silvio Sammartano, “Thermodynamic Data for the Modeling of Lanthanoid(III) Sequestration by Reduced Glutathione in Aqueous Solution,” Journal Of Chemical And Engineering Data, vol. 60, no. 1, pp. 192–201, 2015. View at Publisher · View at Google Scholar
  • Tomris Ozben, “Antioxidant supplementation on cancer risk and during cancer therapy: An update,” Current Topics in Medicinal Chemistry, vol. 15, no. 2, pp. 170–178, 2015. View at Publisher · View at Google Scholar
  • Gaurab Chakrabarti, David E Gerber, and David A Boothman, “Expanding antitumor therapeutic windows by targeting cancer-specific nicotinamide adenine dinucleotide phosphate-biogenesis pathways.,” Clinical pharmacology : advances and applications, vol. 7, pp. 57–68, 2015. View at Publisher · View at Google Scholar
  • Miguel López-Lázaro, “Selective amino acid restriction therapy (SAART): A nonpharmacological strategy against all types of cancer cells,” Oncoscience, vol. 2, no. 10, pp. 857–866, 2015. View at Publisher · View at Google Scholar
  • Shao-Mei Wang, Ze-Qiang Sun, Hong-Yun Li, Jin Wang, and Qing-Yong Liu, “Temporal Identification of Dysregulated Genes and Pathways in Clear Cell Renal Cell Carcinoma Based on Systematic Tracking of Disrupted Modules,” Computational and Mathematical Methods in Medicine, vol. 2015, pp. 1–11, 2015. View at Publisher · View at Google Scholar
  • Batanai Moyo, and Stanley Mukanganyama, “ Antiproliferative Activity of T. welwitschii Extract on Jurkat T Cells In Vitro ,” BioMed Research International, vol. 2015, pp. 1–10, 2015. View at Publisher · View at Google Scholar
  • Szymon Zmorzyński, Grażyna Świderska-Kołacz, Dorota Koczkodaj, and Agata Anna Filip, “Significance of Polymorphisms and Expression of Enzyme-Encoding Genes Related to Glutathione in Hematopoietic Cancers and Solid Tumors,” BioMed Research International, vol. 2015, pp. 1–6, 2015. View at Publisher · View at Google Scholar
  • A A Mahbub, C L Le Maitre, S L Haywood-Small, N A Cross, and N Jordan-Mahy, “Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines.,” Cell death discovery, vol. 1, pp. 15043, 2015. View at Publisher · View at Google Scholar
  • Roberto Carlos Burini, Fernando Moreto, and Yong-Ming Yu, “HIV-Positive Patients Respond to Dietary Supplementation with Cysteine or Glutamine,” Health of HIV Infected People, pp. 245–269, 2015. View at Publisher · View at Google Scholar
  • Zhongling Zhu, and Zhao Yan, “Research progress on therapeutic strategies targeting the glutathione antioxidant system in cancer cells to reverse drug resistance,” Chinese Journal of Clinical Oncology, vol. 42, no. 23, pp. 1143–1147, 2015. View at Publisher · View at Google Scholar
  • Elif Baltaci, Seda Ekizoglu, Elif Sari, Emin Karaman, Turgut Ulutin, and Nur Buyru, “CT120A Acts as an Oncogene in Head and Neck Squamous Cell Carcinoma,” Journal Of Cancer, vol. 6, no. 12, pp. 1255–1259, 2015. View at Publisher · View at Google Scholar
  • Achiraya Tammasakchai, Chaiyavat Chaiyasut, Suda Riengrojpitak, and Prasit Suwannalert, “Unpolished Thai rice prevents ACF formation and dysplastic progression in AOM-induced rats and induces apoptosis through redox alteration in CaCo-2 cells,” Asian Pacific Journal of Cancer Prevention, vol. 16, no. 7, pp. 2827–2832, 2015. View at Publisher · View at Google Scholar
  • Juliana Carron, Angelo Borsarelli Carvalho Brito, Ana Carolina Mourão Torelli, Cristiane Oliveira, Sophie Françoise Mauricette Derchain, Carmen Silvia Passos Lima, and Gustavo Jacob Lourenço, “Association between polymorphisms in xenobiotic detoxification-related genes with prognosis of epithelial ovarian cancer,” Medical Oncology, vol. 33, no. 10, 2016. View at Publisher · View at Google Scholar
  • Petra A. Tsuji, Bradley A. Carlson, Byeong Jae Lee, Vadim N. Gladyshev, and Dolph L. Hatfield, “Interplay of Selenoproteins and Different Antioxidant Systems in Various Cancers,” Selenium, pp. 441–449, 2016. View at Publisher · View at Google Scholar
  • Safnas F. AbdulSalam, Fathima Shazna Thowfeik, and Edward J. Merino, “Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable Liability,” Biochemistry, 2016. View at Publisher · View at Google Scholar
  • Jisu Kim, Jihyun Chae, Jun Soo Kim, Sung-Ho Goh, and Yongdoo Choi, “Photosensitizer-conjugated tryptophan-containing peptide ligands as new dual-targeted theranostics for cancers,” International Journal of Pharmaceutics, 2016. View at Publisher · View at Google Scholar
  • Agnieszka Klupczynska, Szymon Plewa, Wojciech Dyszkiewicz, Mariusz Kasprzyk, Natalia Sytek, and Zenon J. Kokot, “Determination of low-molecular-weight organic acids in non-small cell lung cancer with a new liquid chromatography–tandem mass spectrometry method,” Journal of Pharmaceutical and Biomedical Analysis, vol. 129, pp. 299–309, 2016. View at Publisher · View at Google Scholar
  • Yu Zhou, Shengyun Huang, Hongzhou Shen, Meng Ma, Baocun Zhu, and Dongsheng Zhang, “Detection of glutathione in oral squamous cell carcinoma cells with a fluorescent probe during the course of oxidative stress and apoptosis,” Journal of Oral and Maxillofacial Surgery, 2016. View at Publisher · View at Google Scholar
  • Martina Daga, Chiara Ulllio, Monica Argenziano, Chiara Dianzani, Roberta Cavalli, Francesco Trotta, Carlo Ferretti, Gian Paolo Zara, Casimiro L. Gigliotti, Eric S. Ciamporcero, Piergiorgio Pettazzoni, Denise Corti, Stefania Pizzimenti, and Giuseppina Barrera, “GSH-targeted nanosponges increase doxorubicin-induced toxicity “in vitro” and “in vivo” in cancer cells with high antioxidant defenses,” Free Radical Biology and Medicine, vol. 97, pp. 24–37, 2016. View at Publisher · View at Google Scholar
  • Maja Nešić, Iva Popović, Andreja Leskovac, and Marijana Petković, “Biological activity and binding properties of [Ru(II)(dcbpy)2Cl2] complex to bovine serum albumin, phospholipase A2 and glutathione,” BioMetals, 2016. View at Publisher · View at Google Scholar
  • Kheshwant S. Gill, Philana Fernandes, Tracey R. O'Donovan, Sharon L. McKenna, Kishore K. Doddakula, Derek G. Power, Declan M. Soden, and Patrick F. Forde, “Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response,” Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol. 1866, no. 1, pp. 87–105, 2016. View at Publisher · View at Google Scholar
  • Xi-Feng Zhang, and Sangiliyandi Gurunathan, “Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: An effective anticancer therapy,” International Journal of Nanomedicine, vol. 11, pp. 3655–3675, 2016. View at Publisher · View at Google Scholar
  • Yuan Liu, Qifu Li, Li Zhou, Na Xie, Edouard C Nice, Haiyuan Zhang, Canhua Huang, and Yunlong Lei, “Cancer drug resistance: redox resetting renders a way.,” Oncotarget, vol. 7, no. 27, pp. 42740–42761, 2016. View at Publisher · View at Google Scholar
  • Behnaz Abiri, Roya Kelishadi, Homa Sadeghi, and Fatemeh Azizi-Soleiman, “Effects of Maternal Diet During Pregnancy on the Risk of Childhood Acute Lymphoblastic Leukemia: A Systematic Review,” Nutrition and Cancer, vol. 68, no. 7, pp. 1065–1072, 2016. View at Publisher · View at Google Scholar
  • Xinlei Yu, and Yun Chau Long, “Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis,” Scientific Reports, vol. 6, pp. 30033, 2016. View at Publisher · View at Google Scholar
  • Simona Rupnik, Sytze Buwalda, Stéphane Dejean, Audrey Bethry, Xavier Garric, Jean Coudane, and Benjamin Nottelet, “Redox Reducible and Hydrolytically Degradable PEG-PLA Elastomers as Biomaterial for Temporary Drug-Eluting Medical Devices,” Macromolecular Bioscience, 2016. View at Publisher · View at Google Scholar
  • Uwe Freudenberg, Yingkai Liang, Kristi L. Kiick, and Carsten Werner, “Glycosaminoglycan-Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials,” Advanced Materials, 2016. View at Publisher · View at Google Scholar
  • Birutė Kazbariene, Janina Didziapetrienė, Edita Baltruskeviciene, Robertas Badaras, Loreta Bagdonaitė, Aurelija Krikštaponienė, Linas Zdanavičius, and Eduardas Aleknavicius, “Glutathione and glutathione S-transferase levels in patients with liver metastases of colorectal cancer and other hepatic disorders,” The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, vol. 27, no. 4, pp. 336–341, 2016. View at Publisher · View at Google Scholar
  • Mariagrazia Rinaldi, Maria Caffo, Letteria Minutoli, Herbert Marini, Rosaria Abbritti, Francesco Squadrito, Vincenzo Trichilo, Andrea Valenti, Valeria Barresi, Domenica Altavilla, Marcello Passalacqua, and Gerardo Caruso, “ROS and Brain Gliomas: An Overview of Potential and Innovative Therapeutic Strategies,” International Journal of Molecular Sciences, vol. 17, no. 6, pp. 984, 2016. View at Publisher · View at Google Scholar
  • Didier Dequanter, Paul Delrée, Philippe Lothaire, Pierrick Uzureau, Maureen Van De Velde, Nathalie Nagy, Dany Brohée, Karim Zouaoui Boudjeltia, Isabelle Bar, Vincent Nuyens, Alexandre Rousseau, Luc Vanhamme, and Michel Vanhaeverbeek, “Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma,” Oncology Letters, vol. 11, no. 6, pp. 3660–3668, 2016. View at Publisher · View at Google Scholar
  • Raffaela Silvestre Ignarro, Gustavo Facchini, André Schwambach Vieira, Daniela Rodrigues De Melo, Iscia Lopes-Cendes, Roger Frigério Castilho, and Fabio Rogerio, “Sulfasalazine intensifies temozolomide cytotoxicity in human glioblastoma cells,” Molecular and Cellular Biochemistry, 2016. View at Publisher · View at Google Scholar
  • Xiunan Li, Yumei Wu, Aihui Liu, and Xin Tang, “MiR-27b is epigenetically downregulated in tamoxifen resistant breast cancer cells due to promoter methylation and regulates tamoxifen sensitivity by targeting HMGB3,” Biochemical and Biophysical Research Communications, 2016. View at Publisher · View at Google Scholar
  • Yuki Nomura, Yoko Hirata, Kazutoshi Kiuchi, and Kentaro Oh-Hashi, “Translational and post-translational regulation of mouse cation transport regulator homolog 1,” Scientific Reports, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Gayle M. Gordillo, Ayan Biswas, Savita Khanna, James M. Spieldenner, Xueliang Pan, and Chandan K. Sen, “Multidrug Resistance-associated Protein-1 (MRP-1)-dependent Glutathione Disulfide (GSSG) Efflux as a Critical Survival Factor for Oxidant-enriched Tum,” Journal Of Biological Chemistry, vol. 291, no. 19, pp. 10089–10103, 2016. View at Publisher · View at Google Scholar
  • Sergey Popov, Simon P. Robinson, Hector C. Keun, Karen Barker, Albert Hallsworth, Orli Yogev, Hannah Twebber, Florence I. Raynaud, Chris Jones, Kevin Petrie, Louis Chesler, Arti Sikka, Gilberto S. Almeida, Laura M. Smith, Yann Jamin, Ruth Ruddle, and Alexander Koers, “P53 loss in MYC-driven neuroblastoma leads to metabolic adaptations supporting radioresistance,” Cancer Research, vol. 76, no. 10, pp. 3025–3035, 2016. View at Publisher · View at Google Scholar
  • Moran Benhar, Iart Luca Shytaj, Jonathan S. Stamler, and Andrea Savarino, “Dual targeting of the thioredoxin and glutathione systems in cancer and HIV,” Journal of Clinical Investigation, vol. 126, no. 5, pp. 1630–1639, 2016. View at Publisher · View at Google Scholar
  • Åsa Fransson, Daria Glaessgen, Jessica Alfredsson, Klas G. Wiman, Svetlana Bajalica-Lagercrantz, and Nina Mohell, “Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer,” Journal of Ovarian Research, vol. 9, no. 1, 2016. View at Publisher · View at Google Scholar
  • Yun Lv, Lili Yang, Xiaoxia Mao, Mengjia Lu, Jing Zhao, and Yongmei Yin, “Electrochemical detection of glutathione based on Hg2+-mediated strand displacement reaction strategy,” Biosensors and Bioelectronics, 2016. View at Publisher · View at Google Scholar
  • Sung Jun Lim, Liang Ma, André Schleife, and Andrew M. Smith, “Quantum Dot Surface Engineering: Toward Inert Fluorophores with Compact Size and Bright, Stable Emission,” Coordination Chemistry Reviews, 2016. View at Publisher · View at Google Scholar
  • Filipa Lopes-Coelho, Sofia Gouveia-Fernandes, Luís G Gonçalves, Carolina Nunes, Inês Faustino, Fernanda Silva, Ana Félix, Sofia A Pereira, and Jacinta Serpa, “HNF1β drives glutathione (GSH) synthesis underlying intrinsic carboplatin resistance of ovarian clear cell carcinoma (OCCC).,” Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, vol. 37, no. 4, pp. 4813–29, 2016. View at Publisher · View at Google Scholar
  • Marike W. van Gisbergen, Marcus Cebula, Jie Zhang, Astrid Ottosson-Wadlund, Ludwig Dubois, Philippe Lambin, Kenneth D. Tew, Danyelle M. Townsend, Guido R. M. M. Haenen, Marie-José Drittij-Reijnders, Hisao Saneyoshi, Mika Araki, Yuko Shishido, Yoshihiro Ito, Elias S. J. Arnér, Hiroshi Abe, Ralf Morgenstern, and Katarina Johansson, “Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells,” Molecular Pharmaceutics, 2016. View at Publisher · View at Google Scholar
  • Ziqing Chen, Hainan Zhang, Lina Yang, Hewei Jiang, Shujuan Guo, Yang Li, and Shengce Tao, “Construction of a metabolomics profile of arsenic trioxide effect in gastric carcinoma cell line SGC7901,” Acta Biochimica et Biophysica Sinica, pp. gmw022, 2016. View at Publisher · View at Google Scholar
  • Dong-Xu He, Feng Gu, Fei Gao, Jun-jun Hao, Desheng Gong, Xiao-Ting Gu, Ai-Qin Mao, Jian Jin, Li Fu, and Xin Ma, “Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer,” Scientific Reports, vol. 6, pp. 24706, 2016. View at Publisher · View at Google Scholar
  • Lynn Kirkpatrick, and Garth Powis, “Clinically evaluated cancer drugs inhibiting redox signaling,” Antioxidants & Redox Signaling, 2016. View at Publisher · View at Google Scholar
  • A. L. Furfaro, S. Piras, C. Domenicotti, D. Fenoglio, A. De Luigi, M. Salmona, L. Moretta, U. M. Marinari, M. A. Pronzato, N. Traverso, and M. Nitti, “Role of Nrf2, HO-1 and GSH in Neuroblastoma Cell Resistance to Bortezomib,” Plos One, vol. 11, no. 3, 2016. View at Publisher · View at Google Scholar
  • Nadiah Abu, Swee K. Yeap, Ahmad Z. Mat Pauzi, M. Nadeem Akhtar, Nur R. Zamberi, Jamil Ismail, Seema Zareen, and Noorjahan B. Alitheen, “Dual Regulation of Cell Death and Cell Survival upon Induction of Cellular Stress by Isopimara-7,15-Dien-19-Oic Acid in Cervical Cancer, HeLa Cells In vitro,” Frontiers in Pharmacology, vol. 7, 2016. View at Publisher · View at Google Scholar
  • Nadiah Abu, Swee K. Yeap, Ahmad Z. Mat Pauzi, M. Nadeem Akhtar, Nur R. Zamberi, Jamil Ismail, Seema Zareen, and Noorjahan B. Alitheen, “Dual Regulation of Cell Death and Cell Survival upon Induction of Cellular Stress by Isopimara-7,15-Dien-19-Oic Acid in Cervical Cancer, HeLa Cells In,” Frontiers In Pharmacology, vol. 7, 2016. View at Publisher · View at Google Scholar
  • José M. Estrela, Angel Ortega, Salvador Mena, J. Antoni Sirerol, and Elena Obrador, “Glutathione in metastases: From mechanisms to clinical applications,” Critical Reviews in Clinical Laboratory Sciences, pp. 1–15, 2016. View at Publisher · View at Google Scholar
  • Parvin S. Pakchin, Hamed Mirshekari, Michael R. Hamblin, Mahdi Karimi, Seyed M. Moosavi Basri, and Manouchehr Vossoughi, “Redox-sensitive smart nanosystems for drug and gene delivery,” Current Organic Chemistry, vol. 20, no. 28, pp. 2949–2959, 2016. View at Publisher · View at Google Scholar
  • Francesco Perri, Salvatore Pisconti, and Giuseppina Della Vittoria Scarpati, “P53 mutations and cancer: A tight linkage,” Annals of Translational Medicine, vol. 4, no. 24, 2016. View at Publisher · View at Google Scholar
  • Monika D. Polewski, Rosyli F. Reveron-Thornton, Gregory A. Cherryholmes, Georgi K. Marinov, Karen S. Aboody, and Kaniel Cassady, “Increased expression of system xc- in glioblastoma confers an altered metabolic state and temozolomide resistance,” Molecular Cancer Research, vol. 14, no. 12, pp. 1229–1242, 2016. View at Publisher · View at Google Scholar
  • Chun-Hao Tsai, Pei-Wen Hsieh, Yi-Chen Lee, Chie-Hong Wang, Wen-Chin Chiu, Chun-Wun Lu, Yen-Yun Wang, Stephen Chu-Sung Hu, Tain-Lu Cheng, and Shyng-Shiou F. Yuan, “3′-Hydroxy-4′-methoxy-β-methyl-β-nitrostyrene inhibits tumor growth through ROS generation and GSH depletion in lung cancer cells,” Life Sciences, 2016. View at Publisher · View at Google Scholar
  • Xin An, Cesar Sarmiento, Tao Tan, and Hua Zhu, “Regulation of multidrug resistance by microRNAs in anti-cancer therapy,” Acta Pharmaceutica Sinica B, 2016. View at Publisher · View at Google Scholar
  • Atif Zafar, Swarnendra Singh, and Imrana Naseem, “Cytotoxic activity of soy phytoestrogen coumestrol against human breast cancer MCF-7 cells: Insights into the molecular mechanism,” Food and Chemical Toxicology, 2016. View at Publisher · View at Google Scholar
  • Icard Philippe, and Lincet Hubert, “The reduced concentration of citrate in cancer cells: An indicator of cancer aggressiveness and a possible therapeutic target,” Drug Resistance Updates, vol. 29, pp. 47–53, 2016. View at Publisher · View at Google Scholar
  • Fataneh Karandish, Manas K. Haldar, Seungyong You, Amanda E. Brooks, Benjamin D. Brooks, Bin Guo, Yongki Choi, and Sanku Mallik, “Prostate-Specific Membrane Antigen Targeted Polymersomes for Delivering Mocetinostat and Docetaxel to Prostate Cancer Cell Spheroids,” ACS Omega, vol. 1, no. 5, pp. 952–962, 2016. View at Publisher · View at Google Scholar
  • Ragini Singh, Ajay S. Karakoti, William Self, Sudipta Seal, and Sanjay Singh, “Redox-Sensitive Cerium Oxide Nanoparticles Protect Human Keratinocytes from Oxidative Stress Induced by Glutathione Depletion,” Langmuir, 2016. View at Publisher · View at Google Scholar
  • Otília Menyhárt, Hajnalka Harami-Papp, Saraswati Sukumar, Reinhold Schäfer, Luca Magnani, Oriol de Barrios, and Balázs Győrffy, “Guidelines For The Selection of Functional Assays To Evaluate The Hallmarks of Cancer,” Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2016. View at Publisher · View at Google Scholar
  • Ewa Drozd, Jolanta Krzysztoń-Russjan, Jadwiga Marczewska, Janina Drozd, Irena Bubko, Magda Bielak, Katarzyna Lubelska, Katarzyna Wiktorska, Zdzisław Chilmonczyk, Elżbieta Anuszewska, and Beata Gruber-Bzura, “Up-regulation of glutathione-related genes, enzyme activities and transport proteins in human cervical cancer cells treated with doxorubicin,” Biomedicine & Pharmacotherapy, vol. 83, pp. 397–406, 2016. View at Publisher · View at Google Scholar
  • Annapoorna Sreedhar, Ines Batinić-Haberle, and Yunfeng Zhao, “Redox-Based Therapeutic Strategies in the Treatment of Skin Cancers,” Redox-Active Therapeutics, pp. 485–498, 2016. View at Publisher · View at Google Scholar
  • Goroshinskaja, Nerodo, Malejko, Kachesova, Leonova, Surikova, Frantsiyants, Shalashnaja, and Nemashkalova, “Activity of redox-regulatory systems in the tumor and surrounding tissues in various histological types of tumors,” Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, vol. 10, no. 4, pp. 335–340, 2016. View at Publisher · View at Google Scholar
  • Laith N. AL-Eitan, Doaa M. Rababaʼh, Rami Q. Alkhatib, Rame H. Khasawneh, and Omaiema A. ALjarrah, “GSTM1 and GSTP1 Genetic Polymorphisms and Their Associations With Acute Lymphoblastic Leukemia Susceptibility in a Jordanian Population,” Journal of Pediatric Hematology/Oncology, vol. 38, no. 7, pp. e223–e229, 2016. View at Publisher · View at Google Scholar
  • Qun Fang, XiaoYan Chen, and XuTing Zhi, “Long Non-Coding RNA (LncRNA) Urothelial Carcinoma Associated 1 (UCA1) Increases Multi-Drug Resistance of Gastric Cancer via Downregulating miR-27b,” Medical Science Monitor, vol. 22, pp. 3506–3513, 2016. View at Publisher · View at Google Scholar
  • Balasubramanian Narasimhan, Harmeet Kaur, and Snehlata Yadav, “Diazenyl derivatives and their complexes as anticancer agents,” Anti-Cancer Agents in Medicinal Chemistry, vol. 16, no. 10, pp. 1240–1265, 2016. View at Publisher · View at Google Scholar
  • Dong-Xu He, Guang-Yuan Zhang, Chun-Xiao Lu, Jian Jin, De-Quan Liu, Xiao-Ting Gu, Ai-Qin Mao, and Xin Ma, “Genome-wide profiling of long non-coding RNA expression patterns in anthracycline-resistant breast cancer cells,” International Journal of Oncology, vol. 49, no. 4, pp. 1695–1703, 2016. View at Publisher · View at Google Scholar
  • Michele Telorack, Michael Meyer, Irina Ingold, Marcus Conrad, Wilhelm Bloch, and Sabine Werner, “A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair,” Plos Genetics, vol. 12, no. 1, 2016. View at Publisher · View at Google Scholar
  • Larissa Favaretto Galuppo, Francislaine Aparecida dos Reis Lívero, Gracianny Gomes Martins, Cibele Campos Cardoso, Olair Carlos Beltrame, Liliane Maria Bacaro Klassen, André Vinicius dos Santos Canuto, Aurea Echevarria, José Ederaldo Queiroz Telles, Giseli Klassen, and Alexandra Acco, “ Sydnone 1: A Mesoionic Compound with Antitumoral and Haematological Effects In Vivo ,” Basic & Clinical Pharmacology & Toxicology, vol. 119, no. 1, pp. 41–50, 2016. View at Publisher · View at Google Scholar
  • Alka Dwevedipp. 1–132, 2016. View at Publisher · View at Google Scholar
  • Stephen Childs, Nicolas Haroune, Lee Williams, and Michael Gronow, “Determination of Cellular Glutathione: Glutathione Disulfide Ratio in Prostate Cancer Cells by High Performance Liquid Chromatography with Electrochemical Detection,” Journal of Chromatography A, 2016. View at Publisher · View at Google Scholar
  • Yingkai Liang, and Kristi L. Kiick, “Liposome-Cross-Linked Hybrid Hydrogels for Glutathione-Triggered Delivery of Multiple Cargo Molecules,” Biomacromolecules, 2016. View at Publisher · View at Google Scholar
  • Elif Aşık, Tuğba Nur Aslan, Mürvet Volkan, and N. Tülin Güray, “2-Amino-2-deoxy-glucose conjugated cobalt ferrite magnetic nanoparticle (2DG-MNP) as a targeting agent for breast cancer cells,” Environmental Toxicology and Pharmacology, vol. 41, pp. 272–278, 2016. View at Publisher · View at Google Scholar
  • A. L. Furfaro, N. Traverso, C. Domenicotti, S. Piras, L. Moretta, U. M. Marinari, M. A. Pronzato, and M. Nitti, “The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance,” Oxidative Medicine and Cellular Longevity, vol. 2016, pp. 1–14, 2016. View at Publisher · View at Google Scholar
  • Aysegul Cort, Tomris Ozben, Luciano Saso, Chiara De Luca, and Liudmila Korkina, “Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants,” Oxidative Medicine and Cellular Longevity, vol. 2016, pp. 1–17, 2016. View at Publisher · View at Google Scholar
  • Barbara Marengo, Mariapaola Nitti, Anna Lisa Furfaro, Renata Colla, Chiara De Ciucis, Umberto Maria Marinari, Maria Adelaide Pronzato, Nicola Traverso, and Cinzia Domenicotti, “Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy,” Oxidative Medicine and Cellular Longevity, vol. 2016, pp. 1–16, 2016. View at Publisher · View at Google Scholar
  • Stéphanie Anaís Castaldo, Joana Raquel Freitas, Nadine Vasconcelos Conchinha, and Patrícia Alexandra Madureira, “The Tumorigenic Roles of the Cellular REDOX Regulatory Systems,” Oxidative Medicine and Cellular Longevity, vol. 2016, pp. 1–17, 2016. View at Publisher · View at Google Scholar
  • Kallol Purkait, Saptarshi Chatterjee, Subhendu Karmakar, and Arindam Mukherjee, “Alteration of steric hindrance modulates glutathione resistance and cytotoxicity of three structurally related Ru-II-p-cymene complexes,” Dalton Transactions, vol. 45, no. 20, pp. 8541–8555, 2016. View at Publisher · View at Google Scholar
  • Lluís Pascual, Inmaculada Campos, José-Luis Vivancos, Guillermo Quintás, Alba Loras, M. Carmen Martínez-Bisbal, Ramón Martínez-Máñez, Francisco Boronat, and José Luis Ruiz-Cerdà, “Detection of prostate cancer using a voltammetric electronic tongue,” The Analyst, 2016. View at Publisher · View at Google Scholar
  • J. Gallo, N. Vasimalai, M. T. Fernandez-Arguelles, and M. Bañobre-López, “Green synthesis of multimodal ‘OFF–ON’ activatable MRI/optical probes,” Dalton Trans., 2016. View at Publisher · View at Google Scholar
  • Renata Colla, Maria Adelaide Pronzato, Barbara Marengo, Mario Passalacqua, Nicola Traverso, Cinzia Domenicotti, Alberto Izzotti, Chiara De Ciucis, Daniela Fenoglio, Silvia Ravera, Andrea Speciale, Roberta Ricciarelli, Anna Lisa Furfaro, and Alessandra Pulliero, “Glutathione-mediated antioxidant response and aerobic metabolism: Two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma,” Oncotarget, vol. 7, no. 43, pp. 70715–70737, 2016. View at Publisher · View at Google Scholar
  • Ewa Ignatowicz, Jan Sikora, Jan Oszmiański, Janusz Czapski, Małgorzata Kujawska, Patrycja Kant, Irene Hidalgo Mayoral, and Jadwiga Jodynis-Liebert, “Effect of chokeberry juice on N-nitrosodiethylamine-induced rat liver carcinogenesis,” Journal of Environmental Pathology, Toxicology and Oncology, vol. 35, no. 4, pp. 317–331, 2016. View at Publisher · View at Google Scholar
  • E.I. Surikova, I.A. Goroshinskaja, G.A. Nerodo, E.M. Frantsiyants, M.L. Malejko, E.V. Shalashnaja, P. Kachesova, L.A. Nemashkalova, and A.V. Leonova, “The activity of redox-regulatory systems in the tumor and its surrounding tissues in various histological types of tumor,” Biomeditsinskaya Khimiya, vol. 62, no. 2, pp. 187–192, 2016. View at Publisher · View at Google Scholar
  • Prasit Suwannalert, Thidarat Koomsang, and Witchuda Payuhakrit, “Anti-oxidant, pro-oxidant and anti-inflammatory effects of unpolished rice relevant to colorectal cancer,” Asian Pacific Journal of Cancer Prevention, vol. 17, no. 12, pp. 5047–5056, 2016. View at Publisher · View at Google Scholar
  • Jan Hrabeta, Vojtech Adam, Tomas Eckschlager, Eva Frei, Marie Stiborova, and Rene Kizek, “Metal Containing Cytostatics and Their Interaction with Cellular Thiol Compounds Causing Chemoresistance,” Anti-Cancer Agents In Medicinal Chemistry, vol. 16, no. 6, pp. 686–698, 2016. View at Publisher · View at Google Scholar
  • Ching-Hua Kuo, Chun-Ting Kuo, Yufeng J. Tseng, Cheng-Ying Shen, San-Yuan Wang, Wei-Qing Yang, and Mong-Hsun Tsai, “Distinct metabolic changes in human lung cancer cells with differential radiation sensitivities,” Translational Cancer Research, vol. 5, no. 6, pp. 738–747, 2016. View at Publisher · View at Google Scholar
  • Delphine Denoyer, Michael A. Cater, Helen B. Pearson, Zoe M. Smith, Paul S. Francis, Roxana M. Llanos, Irene Volitakis, Wayne A. Phillips, Peter M. Meggyesy, Shashank Masaldan, and Sharnel A.S. Clatworthy, “Copper as a target for prostate cancer therapeutics: Copper-ionophore pharmacology and altering systemic copper distribution,” Oncotarget, vol. 7, no. 24, pp. 37064–37080, 2016. View at Publisher · View at Google Scholar
  • Ewa Drozd, Beata Gruber, Jadwiga Marczewska, Elzbieta Anuszewska, and Janina Drozd, “Intracellular glutathione level and efflux in human melanoma and cervical cancer cells differing in doxorubicin resistance,” Postepy Higieny i Medycyny Doswiadczalnej, vol. 70, pp. 319–328, 2016. View at Publisher · View at Google Scholar
  • Yu-Guo Yuan, and Sangiliyandi Gurunathan, “Combination of graphene oxide-silver nanoparticle nanocomposites and cisplatin enhances apoptosis and autophagy in human cervical cancer cells,” International Journal of Nanomedicine, vol. 12, pp. 6537–6558, 2017. View at Publisher · View at Google Scholar
  • Steven S. Doerstling, Ciara H. O’Flanagan, and Stephen D. Hursting, “Obesity and Cancer Metabolism: A Perspective on Interacting Tumor–Intrinsic and Extrinsic Factors,” Frontiers in Oncology, vol. 7, 2017. View at Publisher · View at Google Scholar
  • Sonam Pandey, “In vivo antitumor potential of extracts from different parts of Bauhinia variegata linn. Against b16f10 melanoma tumour model in c57bl/6 mice,” Applied Cancer Research, vol. 37, no. 1, 2017. View at Publisher · View at Google Scholar
  • Madduri Srinivasarao, and Philip S. Low, “Ligand-Targeted Drug Delivery,” Chemical Reviews, 2017. View at Publisher · View at Google Scholar
  • Maria Skamagki, Cristina Correia, Percy Yeung, Timour Baslan, Samuel Beck, Cheng Zhang, Christian A. Ross, Lam Dang, Zhong Liu, Simona Giunta, Tzu-Pei Chang, Joye Wang, Aparna Ananthanarayanan, Martina Bohndorf, Benedikt Bosbach, James Adjaye, Hironori Funabiki, Jonghwan Kim, Scott Lowe, James J. Collins, Chi-Wei Lu, Hu Li, Rui Zhao, and Kitai Kim, “ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors,” Nature Cell Biology, 2017. View at Publisher · View at Google Scholar
  • Xian Zhang, Xiang Li, Qidong You, and Xiaojin Zhang, “Prodrug strategy for cancer cell-specific targeting: A recent overview,” European Journal of Medicinal Chemistry, 2017. View at Publisher · View at Google Scholar
  • Siti Maziras Makhtar, Azlan Husin, Abdul Aziz Baba, and Ravindran Ankathil, “Association of GSTM1, GSTT1 and GSTP1 Ile105Val polymorphisms with clinical response to imatinib mesylate treatment among Malaysian chronic myeloid leukaemia patients,” Journal of Genetics, 2017. View at Publisher · View at Google Scholar
  • Kylie O'Brien, Avni Sali, Kylie O’Brien, and Avni Sali, “Additional Therapies and Innovative Technologies,” A Clinician's Guide to Integrative Oncology, pp. 231–303, 2017. View at Publisher · View at Google Scholar
  • Andrew G.M. Morgan, Dinesh Babu, Karim Michail, and Arno G. Siraki, “An evaluation of myeloperoxidase-mediated bio-activation of NSAIDs in promyelocytic leukemia (HL-60) cells for potential cytotoxic selectivity,” Toxicology Letters, 2017. View at Publisher · View at Google Scholar
  • Chia-Wen Liu, Hsiang-Fong Kao, Michael Hsiao, Min-Liang Kuo, Kuo-Tai Hua, Kai-Chun Li, Ruey-Long Hong, Jenq-Yuh Ko, and Ching-Ting Tan, “Histone methyltransferase G9a drives chemotherapy resistance by regulating the glutamate–cysteine ligase catalytic subunit in head and neck squamous cell carcinoma,” Molecular Cancer Therapeutics, vol. 16, no. 7, pp. 1421–1434, 2017. View at Publisher · View at Google Scholar
  • Ujjwol Barman, Gargi Mukhopadhyay, Namami Goswami, Siddhartha Sankar Ghosh, and Roy P. Paily, “Detection of Glutathione by Glutathione-S-Transferase-Nanoconjugate Ensemble Electrochemical Device,” IEEE Transactions on NanoBioscience, vol. 16, no. 4, pp. 271–279, 2017. View at Publisher · View at Google Scholar
  • Carsten Berndt, and Christopher Horst Lillig, “Glutathione, Glutaredoxins, and Iron,” Antioxidants & Redox Signaling, 2017. View at Publisher · View at Google Scholar
  • Yun Lv, Mengjia Lu, Yucai Yang, Yongmei Yin, and Jing Zhao, “Electrochemical detection of intracellular glutathione based on ligand exchange assisted release of DNA-templated silver nanoparticles,” Sensors and Actuators B: Chemical, vol. 244, pp. 151–156, 2017. View at Publisher · View at Google Scholar
  • Malav Trivedi, Amit Singh, Meghna Talekar, Grishma Pawar, Parin Shah, and Mansoor Amiji, “MicroRNA-34a Encapsulated in Hyaluronic Acid Nanoparticles Induces Epigenetic Changes with Altered Mitochondrial Bioenergetics and Apoptosis in Non-Small-Cell Lung Cancer Cells,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Jialing Zhang, Clara L Feider, Chandandeep Nagi, Wendong Yu, Stacey A Carter, James Suliburk, Hop S Tran Cao, and Livia S Eberlin, “Detection of Metastatic Breast and Thyroid Cancer in Lymph Nodes by Desorption Electrospray Ionization Mass Spectrometry Imaging.,” Journal of the American Society for Mass Spectrometry, vol. 28, no. 6, pp. 1166–1174, 2017. View at Publisher · View at Google Scholar
  • Muhammad Hassan Raza, Sami Siraj, Abida Arshad, Usman Waheed, Fahad Aldakheel, Shatha Alduraywish, and Muhammad Arshad, “ROS-modulated therapeutic approaches in cancer treatment,” Journal of Cancer Research and Clinical Oncology, 2017. View at Publisher · View at Google Scholar
  • Zhuqing Huang, Guotao Yang, Tao Shen, Xiaoning Wang, Haizhen Li, and Dongmei Ren, “Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells,” Biomedicine & Pharmacotherapy, vol. 89, pp. 623–631, 2017. View at Publisher · View at Google Scholar
  • Mariapaola Nitti, Sabrina Piras, Umberto Marinari, Lorenzo Moretta, Maria Pronzato, and Anna Furfaro, “HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation,” Antioxidants, vol. 6, no. 2, pp. 29, 2017. View at Publisher · View at Google Scholar
  • Tonje Haukaas, Leslie Euceda, Guro Giskeødegård, and Tone Bathen, “Metabolic Portraits of Breast Cancer by HR MAS MR Spectroscopy of Intact Tissue Samples,” Metabolites, vol. 7, no. 2, pp. 18, 2017. View at Publisher · View at Google Scholar
  • Nobumichi Ohoka, Katsunori Nagai, Norihito Shibata, Takayuki Hattori, Hiroshi Nara, Nobuo Cho, and Mikihiko Naito, “SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib,” Cancer Science, 2017. View at Publisher · View at Google Scholar
  • Mohammad Shadid, Stephen Bowlin, and Jayaprakasam Bolleddula, “Catabolism of antibody drug conjugates and characterization methods,” Bioorganic & Medicinal Chemistry, 2017. View at Publisher · View at Google Scholar
  • Yong-qiang Ren, Hui-jun Wang, Yong-qing Zhang, and Yan-bing Liu, “WBP2 modulates G1/S transition in ER+ breast cancer cells and is a direct target of miR-206,” Cancer Chemotherapy and Pharmacology, 2017. View at Publisher · View at Google Scholar
  • Benoît Bertrand, Julio Fernandez-Cestau, Jesus Angulo, Marco M. D. Cominetti, Zoë A. E. Waller, Mark Searcey, Maria A. O’Connell, and Manfred Bochmann, “ Cytotoxicity of Pyrazine-Based Cyclometalated (C^N pz ^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties ,” Inorganic Chemistry, 2017. View at Publisher · View at Google Scholar
  • Shinya Toyokuni, Fumiya Ito, Kyoko Yamashita, Yasumasa Okazaki, and Shinya Akatsuka, “Iron and thiol redox signaling in cancer: an exquisite balance to escape ferroptosis,” Free Radical Biology and Medicine, 2017. View at Publisher · View at Google Scholar
  • Jong-Lyel Roh, Eun Hye Kim, Hyejin Jang, and Daiha Shin, “Aspirin plus sorafenib potentiates cisplatin cytotoxicity in resistant head and neck cancer cells through xCT inhibition,” Free Radical Biology and Medicine, vol. 104, pp. 1–9, 2017. View at Publisher · View at Google Scholar
  • Koorosh Ashrafi, Clare L. Heaysman, Gary J. Phillips, Andrew W. Lloyd, and Andrew L. Lewis, “Towards Hypoxia-responsive Drug-eluting Embolization Beads,” International Journal of Pharmaceutics, 2017. View at Publisher · View at Google Scholar
  • Yen-Yun Wang, Yuk-Kwan Chen, Ya-Ling Hsu, Wen-Chin Chiu, Chun-Hao Tsai, Stephen Chu-Sung Hu, Pei-Wen Hsieh, and Shyng-Shiou F. Yuan, “Synthetic β-nitrostyrene derivative CYT-Rx20 as inhibitor of oral cancer cell proliferation and tumor growth through glutathione suppression and reactive oxygen species induction,” Head & Neck, 2017. View at Publisher · View at Google Scholar
  • Xu-jiao Yu, Wei Zhao, Yu-jie Li, Feng-xian Li, Zhong-jie Liu, Hua-li Xu, Lu-ying Lai, Rui Xu, and Shi-yuan Xu, “Neurotoxicity Comparison of Two Types of Local Anaesthetics: Amide-Bupivacaine versus Ester-Procaine,” Scientific Reports, vol. 7, pp. 45316, 2017. View at Publisher · View at Google Scholar
  • Ancély F. dos Santos, Letícia F. Terra, Rosangela A. M. Wailemann, Talita C. Oliveira, Vinícius de Morais Gomes, Marcela Franco Mineiro, Flávia Carla Meotti, Alexandre Bruni-Cardoso, Maurício S. Baptista, and Leticia Labriola, “Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells,” BMC Cancer, vol. 17, no. 1, 2017. View at Publisher · View at Google Scholar
  • Annapina Russo, Assunta Saide, Silvia Smaldone, Raffaella Faraonio, and Giulia Russo, “Role of uL3 in Multidrug Resistance in p53-Mutated Lung Cancer Cells,” International Journal of Molecular Sciences, vol. 18, no. 3, pp. 547, 2017. View at Publisher · View at Google Scholar
  • Alessio Menga, Erika M. Palmieri, Antonia Cianciulli, Vittoria Infantino, Massimiliano Mazzone, Antonio Scilimati, Ferdinando Palmieri, Alessandra Castegna, and Vito Iacobazzi, “ SLC25A26 overexpression impairs cell function via mtDNA hypermethylation and rewiring of methyl metabolism ,” The FEBS Journal, 2017. View at Publisher · View at Google Scholar
  • Tianci Song, Yan Wang, Wei Du, Sha Cao, Yuan Tian, and Yanchun Liang, “The method for breast cancer grade prediction and pathway analysis based on improved multiple kernel learning,” Journal of Bioinformatics and Computational Biology, vol. 15, no. 01, pp. 1650037, 2017. View at Publisher · View at Google Scholar
  • Agnieszka Klupczynska, Paweł Dereziński, Timothy J. Garrett, Vanessa Y. Rubio, Wojciech Dyszkiewicz, Mariusz Kasprzyk, and Zenon J. Kokot, “Study of early stage non-small-cell lung cancer using Orbitrap-based global serum metabolomics,” Journal of Cancer Research and Clinical Oncology, 2017. View at Publisher · View at Google Scholar
  • Sylwia Wrotek, Krzysztof Domagalski, Tomasz Jędrzejewski, Eliza Dec, and Wiesław Kozak, “Buthionine sulfoximine, a glutathione depletor, attenuates endotoxic fever and reduces IL-1β and IL-6 level in rats,” Cytokine, vol. 90, pp. 31–37, 2017. View at Publisher · View at Google Scholar
  • Xinhui Fu, Xinjuan Fan, Jun Hu, Hongzhi Zou, Zhiting Chen, Qi Liu, Beibei Ni, Xiaoli Tan, Qiao Su, Jingxuan Wang, Lei Wang, and Jianping Wang, “Overexpression of MSK1 is associated with tumor aggressiveness and poor prognosis in colorectal cancer,” Digestive and Liver Disease, 2017. View at Publisher · View at Google Scholar
  • Allimuthu T. Dharmaraja, “Role of Reactive Oxygen Species (ROS) in Therapeutics and Drug Resistance in Cancer and Bacteria,” Journal of Medicinal Chemistry, 2017. View at Publisher · View at Google Scholar
  • Rana Abdelnabi, Leen Delang, and Johan Neyts, “Glutathione is a highly efficient thermostabilizer of poliovirus Sabin strains,” Vaccine, 2017. View at Publisher · View at Google Scholar
  • Ghassan M. Saed, Michael P. Diamond, and Nicole M. Fletcher, “Updates of the role of oxidative stress in the pathogenesis of ovarian cancer,” Gynecologic Oncology, 2017. View at Publisher · View at Google Scholar
  • M. Gisbert-Garzarán, M. Manzano, and M. Vallet-Regí, “Self-Immolative Chemistry In Nanomedicine,” Chemical Engineering Journal, 2017. View at Publisher · View at Google Scholar
  • Bassem Y. Sheikh, Md. Moklesur Rahman Sarker, Muhamad Noor Alfarizal Kamarudin, and Gokula Mohan, “Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines,” Biomedicine and Pharmacotherapy, vol. 96, pp. 834–846, 2017. View at Publisher · View at Google Scholar
  • Manuel Bañobre-Lopéz, Lorena García-Hevia, M. Fatima Cerqueira, Francisco Rivadulla, and Juan Gallo, “Tunable Performance of Manganese Oxide Nanostructures as MRI Contrast Agents,” Chemistry - A European Journal, 2017. View at Publisher · View at Google Scholar
  • Osama A. Abu-Zinadah, Rania Abd El Hamid Hussein, and Ayman I. Elkady, “Crude flavonoid extract of the medicinal herb Nigella sativa inhibits proliferation and induces apoptosis in breast cancer cells,” Journal of Biomaterials and Tissue Engineering, vol. 7, no. 12, pp. 1235–1249, 2017. View at Publisher · View at Google Scholar
  • Zhongling Zhu, Shuangshuang Du, Yibo Du, Jing Ren, Guoguang Ying, and Zhao Yan, “Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis,” Journal of Neurochemistry, 2017. View at Publisher · View at Google Scholar
  • S. Lalitha Gavya, Neha Arora, and Siddhartha Sankar Ghosh, “ Retention of functional characteristics of gulathione- S -transferase and lactate dehydrogenase-A in fusion protein ,” Preparative Biochemistry and Biotechnology, 2017. View at Publisher · View at Google Scholar
  • Jan F. Stevens, Johana S. Revel, and Claudia S. Maier, “Mitochondria-Centric Review of Polyphenol Bioactivity in Cancer Models,” Antioxidants & Redox Signaling, 2017. View at Publisher · View at Google Scholar
  • Valery V. Khramtsov, “In vivo molecular EPR-based spectroscopy and imaging of tumor microenvironment and redox using functional paramagnetic probes,” Antioxidants & Redox Signaling, 2017. View at Publisher · View at Google Scholar
  • Yuan Tian, Wei Du, Sha Cao, Yue Wu, Ning Dong, Yan Wang, and Ying Xu, “Systematic analyses of glutamine and glutamate metabolisms across different cancer types.,” Chinese journal of cancer, vol. 36, no. 1, pp. 88, 2017. View at Publisher · View at Google Scholar
  • Minlan Yang, Yanru Li, Xiangfeng Shen, Yang Ruan, Yan Lu, Xiangshu Jin, Peiye Song, Yantong Guo, Xiaoli Zhang, Huinan Qu, Yijia Shao, and Chengshi Quan, “CLDN6 promotes chemoresistance through GSTP1 in human breast cancer,” Journal of Experimental & Clinical Cancer Research, vol. 36, no. 1, 2017. View at Publisher · View at Google Scholar
  • Cheng Zhang, Maria Skamagki, Zhong Liu, Aparna Ananthanarayanan, Rui Zhao, Hu Li, and Kitai Kim, “Biological Significance of the Suppression of Oxidative Phosphorylation in Induced Pluripotent Stem Cells,” Cell Reports, vol. 21, no. 8, pp. 2058–2065, 2017. View at Publisher · View at Google Scholar
  • Jessie A. Brown, Yoshiya Yonekubo, Nicole Hanson, Ana Sastre-Perona, Alice Basin, Julie A. Rytlewski, Igor Dolgalev, Shane Meehan, Aristotelis Tsirigos, Slobodan Beronja, and Markus Schober, “TGF-β-Induced Quiescence Mediates Chemoresistance of Tumor-Propagating Cells in Squamous Cell Carcinoma,” Cell Stem Cell, vol. 21, no. 5, pp. 650–664.e8, 2017. View at Publisher · View at Google Scholar
  • Yu-Zhi Zhou, Ming-Liang Yan, Xue-Mei Qin, Xiang Zhang, Guan-Hua Du, Li Gao, and Jian-Qin Zhang, “Metabonomics approach to assessing the metabolism variation and gender gap of Drosophila melanogaster in aging process,” Experimental Gerontology, vol. 98, pp. 110–119, 2017. View at Publisher · View at Google Scholar
  • Guoyou Huang, Fei Li, Xin Zhao, Yufei Ma, Yuhui Li, Min Lin, Guorui Jin, Tian Jian Lu, Guy M. Genin, and Feng Xu, “Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment,” Chemical Reviews, 2017. View at Publisher · View at Google Scholar
  • Dorelia Lipsa, Josefa Barrero-Moreno, and Mehmet Coelhan, “Exposure to selected limonene oxidation products: 4-OPA, IPOH, 4-AMCH induces oxidative stress and inflammation in human lung epithelial cell lines,” Chemosphere, 2017. View at Publisher · View at Google Scholar
  • Shao Thing Teoh, and Sophia Y. Lunt, “Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyond,” Wiley Interdisciplinary Reviews: Systems Biology and Medicine, pp. e1406, 2017. View at Publisher · View at Google Scholar
  • Xin Wang, Mengjie Gu, Tan Boon Toh, Nurrul Lissa Binti Abdullah, and Edward Kai-Hua Chow, “Stimuli-Responsive Nanodiamond-Based Biosensor for Enhanced Metastatic Tumor Site Detection,” SLAS TECHNOLOGY: Translating Life Sciences Innovation, pp. 247263031773549, 2017. View at Publisher · View at Google Scholar
  • Mahya Mehrmohamadi, Seong Ho Jeong, and Jason W. Locasale, “Molecular features that predict the response to antimetabolite chemotherapies,” Cancer & Metabolism, vol. 5, no. 1, 2017. View at Publisher · View at Google Scholar
  • Saban Kalay, Asuman Demiroglu-Zergeroglu, Aysegul Dogan, and Ali Turkan, “Dicholoroacetate exerts anti-cancer activity on human renal cell carcinoma cells,” Turkish Journal of Biochemistry, vol. 42, no. 5, pp. 577–585, 2017. View at Publisher · View at Google Scholar
  • Farzin Safaei, Saeed Mehrzadi, Hossein Khadem Haghighian, Azam Hosseinzadeh, Ali Nesari, Mojtaba Dolatshahi, Mahdi Esmaeilizadeh, and Mehdi Goudarzi, “Protective effects of gallic acid against methotrexate-induced toxicity in rats,” Acta Chirurgica Belgica, pp. 1–9, 2017. View at Publisher · View at Google Scholar
  • Shamik Das, William P. Jackson, Jeevan K. Prasain, Ann Hanna, Sarah K. Bailey, J. Allan Tucker, Sejong Bae, Landon S. Wilson, Rajeev S. Samant, Stephen Barnes, and Lalita A. Shevde, “Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling,” Scientific Reports, vol. 7, pp. 40773, 2017. View at Publisher · View at Google Scholar
  • Shao-Bin Cheng, Hsiao-Tien Liu, Sin-Yuan Chen, Ping-Ting Lin, Chia-Yu Lai, and Yi-Chia Huang, “Changes of Oxidative Stress, Glutathione, and Its Dependent Antioxidant Enzyme Activities in Patients with Hepatocellular Carcinoma before and after Tumor Resection,” Plos One, vol. 12, no. 1, pp. e0170016, 2017. View at Publisher · View at Google Scholar
  • Martin Beaumont, Mireille Andriamihaja, Lucie Armand, Marta Grauso, Florence Jaffrézic, Denis Laloë, Marco Moroldo, Anne-Marie Davila, Daniel Tomé, François Blachier, and Annaïg Lan, “Epithelial response to a high-protein diet in rat colon,” BMC Genomics, vol. 18, no. 1, 2017. View at Publisher · View at Google Scholar
  • Saroj Kumar, Xia Liu, Ferenc Borondics, Qunfeng Xiao, Renfei Feng, Erik Goormaghtigh, and Fredrik Nikolajeff, “Insights into Biochemical Alteration in Cancer-Associated Fibroblasts by using Novel Correlative Spectroscopy,” ChemistryOpen, 2017. View at Publisher · View at Google Scholar
  • Ming-Jenn Chen, Ya-Min Cheng, Chien-Chung Chen, Yu-Chieh Chen, and Ching-Ju Shen, “MiR-148a and miR-152 reduce tamoxifen resistance in ER+ breast cancer via downregulating ALCAM,” Biochemical and Biophysical Research Communications, 2017. View at Publisher · View at Google Scholar
  • Yingkai Liang, Linqing Li, Rebecca A. Scott, and Kristi L. Kiick, “ 50th Anniversary Perspective : Polymeric Biomaterials: Diverse Functions Enabled by Advances in Macromolecular Chemistry ,” Macromolecules, 2017. View at Publisher · View at Google Scholar
  • Catherine Ghosh, Tridib Mondal, and Kankan Bhattacharyya, “Enzyme Activity of α-chymotrypsin: Deactivation by Gold Nano-cluster and Reactivation by Glutathione,” Journal of Colloid and Interface Science, 2017. View at Publisher · View at Google Scholar
  • Jun Chul Park, Jeonghoon Han, Min-Chul Lee, Jung Soo Seo, and Jae-Seong Lee, “Effects of triclosan (TCS) on fecundity, the antioxidant system, and oxidative stress-mediated gene expression in the copepod Tigriopus japonicus,” Aquatic Toxicology, vol. 189, pp. 16–24, 2017. View at Publisher · View at Google Scholar
  • Lin Li, and Po Sing Leung, “Pancreatic Cancer, Pancreatitis, and Oxidative Stress,” Gastrointestinal Tissue, pp. 173–186, 2017. View at Publisher · View at Google Scholar
  • E.I. Surikova, I.A. Goroshinskaya, E.M. Frantsiyants, E.V. Shalashnaja, G.A. Nerodo, I.V. Neskubina, P.S. Kachesova, L.A. Nemashkalova, and A.V. Chudilova, “The activity of redox-regulatory systems in the primary and recurrence tumors in vulvar cancer,” Biomeditsinskaya Khimiya, vol. 63, no. 4, pp. 321–326, 2017. View at Publisher · View at Google Scholar
  • Oleg Shuvalov, Olga Fedorova, Alexey Petukhov, Alexandra Daks, Elena Vasileva, and Nickolai A. Barlev, “One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy,” Oncotarget, vol. 8, no. 14, pp. 23955–23977, 2017. View at Publisher · View at Google Scholar
  • Li Yang, Zun'Min Zhu, Zheng Hu, Min Xiao, Ya'Nan Liu, Na Zhang, Xiao'Yi Ding, Wei Zhang, Ke'Feng Shen, Liang Huang, Jian'Feng Zhou, and Sen Cui, “Novel impact of the DNMT3A R882H mutation on GSH metabolism in a K562 cell model established by TALENs,” Oncotarget, vol. 8, no. 18, pp. 30395–30409, 2017. View at Publisher · View at Google Scholar
  • Daniele Dalzoppo, Veronica Di Paolo, Laura Calderan, Gianfranco Pasut, Antonio Rosato, Anna Maria Caccuri, and Luigi Quintieri, “Thiol-activated anticancer agents: The state of the art,” Anti-Cancer Agents in Medicinal Chemistry, vol. 17, no. 1, pp. 4–20, 2017. View at Publisher · View at Google Scholar
  • Christine Le Maitre, Sarah Haywood-Small, Amani Mahbub, Neil Cross, and Nicola Jordan-Mahy, “Dietary polyphenols influence antimetabolite agents: Methotrexate, 6-mercaptopurine and 5-fluorouracil in leukemia cell lines,” Oncotarget, vol. 8, no. 62, pp. 104877–104893, 2017. View at Publisher · View at Google Scholar
  • Long Cui, Bo Liang, Minhui Zhu, Joseph Kwong, Hongliang Zheng, Yihua Yang, and Chi Chiu Wang, “Inhibition of coiled coil domain containing protein 69 enhances platinum-induced apoptosis in ovarian cancer cells,” Oncotarget, vol. 8, no. 60, pp. 101634–101648, 2017. View at Publisher · View at Google Scholar
  • Cheng Gao, Fan Tang, Jianxiang Zhang, Simon M. Y. Lee, and Ruibing Wang, “Glutathione-responsive nanoparticles based on a sodium alginate derivative for selective release of doxorubicin in tumor cells,” J. Mater. Chem. B, 2017. View at Publisher · View at Google Scholar
  • Adam I. Green, Julio Fernandez-Cestau, David L. Hughes, Mark Searcey, Manfred Bochmann, Morwen Williams, Maria A. O'Connell, and Benoît Bertrand, “(C^Npz^C)AuIII complexes of acyclic carbene ligands: Synthesis and anticancer properties,” Dalton Transactions, vol. 46, no. 39, pp. 13397–13408, 2017. View at Publisher · View at Google Scholar
  • Daisy L. Wong, Angel Zhang, Abayomi S. Faponle, Sam P. de Visser, and Martin J. Stillman, “Glutathione binding to dirhodium tetraacetate: a spectroscopic, mass spectral and computational study of an anti-tumour compound,” Metallomics, 2017. View at Publisher · View at Google Scholar
  • Weon Sup Shin, Soon Ki Park, Peter Verwilst, Seyoung Koo, Joung Hae Lee, Sung-Gil Chi, and Jong Seung Kim, “Targeted combinational therapy inducing mitochondrial dysfunction,” Chem. Commun., 2017. View at Publisher · View at Google Scholar
  • Rui Zhang, Peishan Hu, Qingce Zang, Xiaofei Yue, Zhi Zhou, Xiaoyu Xu, Jing Xu, Shanshan Li, Yanhua Chen, Boqin Qiang, Xiaozhong Peng, Wei Han, Ruiping Zhang, and Zeper Abliz, “LC-MS-based metabolomics reveals metabolic signatures related to glioma stem-like cell self-renewal and differentiation,” RSC Adv., vol. 7, no. 39, pp. 24221–24232, 2017. View at Publisher · View at Google Scholar
  • Yuejing Jiang, Juan Cheng, Chengyu Yang, Yongzhou Hu, Jia Li, Yifeng Han, Yi Zang, and Xin Li, “An ultrasensitive fluorogenic probe for revealing the role of glutathione in chemotherapy resistance,” Chem. Sci., 2017. View at Publisher · View at Google Scholar
  • Monica Carril, “Activatable probes for diagnosis and biomarker detection by MRI,” J. Mater. Chem. B, 2017. View at Publisher · View at Google Scholar
  • Dayoung Lee, Keunsoo Jeong, Xiao Luo, Gayoung Kim, Youjun Yang, Xiaoqiang Chen, Sehoon Kim, and Juyoung Yoon, “Near-infrared fluorescent probes for the detection of glutathione and their application in the fluorescence imaging of living cells and tumor-bearing mice,” J. Mater. Chem. B, 2017. View at Publisher · View at Google Scholar
  • Ayman I. Elkady, Osama A. Abu-Zinadah, and Rania Abd El Hamid Hussein, “Crude flavonoid extract of medicinal herb Zingibar Officinale inhibits proliferation and induces apoptosis in hepatocellular carcinoma cells,” Oncology Research, vol. 25, no. 6, pp. 897–912, 2017. View at Publisher · View at Google Scholar
  • Bhuvanesh Sukhlal Kalal, Dinesh Upadhya, and Vinitha Ramanath Pai, “Chemotherapy resistance mechanisms in advanced skin cancer,” Oncology Reviews, vol. 11, no. 1, pp. 19–25, 2017. View at Publisher · View at Google Scholar
  • Stephen Childs, Nicolas Haroune, Lee Williams, and Michael Gronow, “Investigation of the Low Molecular Weight Thiol Composition in a Metastatic Prostate Cancer Cell Line (LNCaP) by LC-UV-MS and NMR after Labelling with the Ellman Reagent,” American Journal of Analytical Chemistry, vol. 08, no. 01, pp. 1–18, 2017. View at Publisher · View at Google Scholar
  • Shilpa Kuttikrishnan, Kodappully S. Siveen, Kirti S. Prabhu, Abdul Quaiyoom Khan, Sabah Akhtar, Jericha M. Mateo, Maysaloun Merhi, Ruba Taha, Halima El Omri, Fatima Mraiche, Said Dermime, and Shahab Uddin, “Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia,” Leukemia & Lymphoma, pp. 1–13, 2018. View at Publisher · View at Google Scholar
  • Hilal Taymaz-Nikerel, Muhammed Erkan Karabekmez, Serpil Eraslan, and Betül Kırdar, “Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Parichaya Aimvijarn, Witchuda Payuhakrit, Teerapat Rodboon, and Prasit Suwannalert, “Nymphaea pubescens induces apoptosis, suppresses cellular oxidants-related cell invasion in b16 melanoma cells,” Pharmaceutical Sciences, vol. 24, no. 3, pp. 199–206, 2018. View at Publisher · View at Google Scholar
  • Satyendra C. Tripathi, Johannes F. Fahrmann, Jody V. Vykoukal, Jennifer B. Dennison, and Samir M. Hanash, “Targeting metabolic vulnerabilities of cancer: Small molecule inhibitors in clinic,” Cancer Reports, pp. e1131, 2018. View at Publisher · View at Google Scholar
  • Yashar Mesbahi, Ali Zekri, Seyed H. Ghaffari, Parvaneh Sadat Tabatabaie, Shahin Ahmadian, and Ardeshir Ghavamzadeh, “Blockade of JAK2/STAT3 intensifies the anti-tumor activity of arsenic trioxide in acute myeloid leukemia cells: Novel synergistic mechanism via the mediation of reactive oxygen species,” European Journal of Pharmacology, vol. 834, pp. 65–76, 2018. View at Publisher · View at Google Scholar
  • Anisha Viswanathan, Anastasia Zhurina, Benedicta Assoah, Aleksi Paakkunainen, Aliyu Musa, Dinesh Kute, Konda Mani Saravanan, Olli Yli-Harja, Nuno R. Candeias, and Meenakshisundaram Kandhavelu, “Decane-1,2-diol derivatives as potential antitumor agents for the treatment of glioblastoma,” European Journal of Pharmacology, 2018. View at Publisher · View at Google Scholar
  • Tal Hirschhorn, and Brent R. Stockwell, “The Development of the Concept of Ferroptosis,” Free Radical Biology and Medicine, 2018. View at Publisher · View at Google Scholar
  • Wenbo Shi, Bo Song, Wenjing Shi, Xiaodan Qin, Zhiwei Liu, Mingqian Tan, Liu Wang, Fengling Song, and Jingli Yuan, “ Bimodal Phosphorescence–Magnetic Resonance Imaging Nanoprobes for Glutathione Based on MnO 2 Nanosheet–Ru(II) Complex Nanoarchitecture ,” ACS Applied Materials & Interfaces, 2018. View at Publisher · View at Google Scholar
  • Liang Wang, Wen Peng, Tianming Wu, Pengchi Deng, and Ying-Lan Zhao, “Increased glutamine anabolism sensitizes non-small cell lung cancer to gefitinib treatment,” Cell Death Discovery, vol. 5, no. 1, 2018. View at Publisher · View at Google Scholar
  • Kirti S. Prabhu, Kodappully Sivaraman Siveen, Shilpa Kuttikrishnan, Ahmad N. Iskandarani, Abdul Q. Khan, Maysaloun Merhi, Halima E. Omri, Said Dermime, Tamam El-Elimat, Nicholas H. Oberlies, Feras Q. Alali, and Shahab Uddin, “Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines,” Frontiers in Pharmacology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Dorota Wrześniok, Zuzanna Rzepka, Michalina Respondek, Artur Beberok, Jakub Rok, Karolina Szczepanik, and Ewa Buszman, “Caffeine modulates growth and vitality of human melanotic COLO829 and amelanotic C32 melanoma cells: Preliminary findings,” Food and Chemical Toxicology, 2018. View at Publisher · View at Google Scholar
  • Kun Zhang, Yu Cheng, Weiwei Ren, Liping Sun, Chang Liu, Dan Wang, Lehang Guo, Huixiong Xu, and Yongxiang Zhao, “Coordination-Responsive Longitudinal Relaxation Tuning as a Versatile MRI Sensing Protocol for Malignancy Targets,” Advanced Science, pp. 1800021, 2018. View at Publisher · View at Google Scholar
  • N.V. Kurnosov, V.S. Leontiev, and V.A. Karachevtsev, “Glutathione influence on the photoluminescence from semiconducting single-walled carbon nanotubes compared with other thiol compounds,” Chemical Physics, 2018. View at Publisher · View at Google Scholar
  • Sanaya Bamji-Stocke, Victor van Berkel, Donald M. Miller, and Hermann B. Frieboes, “A review of metabolism-associated biomarkers in lung cancer diagnosis and treatment,” Metabolomics, vol. 14, no. 6, 2018. View at Publisher · View at Google Scholar
  • Sofia C. Nunes, Cristiano Ramos, Filipa Lopes-Coelho, Catarina O. Sequeira, Fernanda Silva, Sofia Gouveia-Fernandes, Armanda Rodrigues, António Guimarães, Margarida Silveira, Sofia Abreu, Vítor E. Santo, Catarina Brito, Ana Félix, Sofia A. Pereira, and Jacinta Serpa, “Cysteine allows ovarian cancer cells to adapt to hypoxia and to escape from carboplatin cytotoxicity,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Ankita Bansal, and M. Celeste Simon, “Glutathione metabolism in cancer progression and treatment resistance,” The Journal of Cell Biology, pp. jcb.201804161, 2018. View at Publisher · View at Google Scholar
  • Sofia Nunes, and Jacinta Serpa, “Glutathione in Ovarian Cancer: A Double-Edged Sword,” International Journal of Molecular Sciences, vol. 19, no. 7, pp. 1882, 2018. View at Publisher · View at Google Scholar
  • Kai Song, Wenyuan Zhao, Wen Wang, Na Zhang, Kai Wang, and Zhiqiang Chang, “Individualized predictive signatures for 5-fluorouracil-based chemotherapy in right- and left-sided colon cancer,” Cancer Science, 2018. View at Publisher · View at Google Scholar
  • Isadora C.B. Pavan, Fernando R. Silva, Rodrigo E. Tamura, Fernando M. Simabuco, Mirian G. Morale, and Ana P. Morelli, “p53 and metabolism: From mechanism to therapeutics,” Oncotarget, vol. 9, no. 34, pp. 23780–23823, 2018. View at Publisher · View at Google Scholar
  • Claudia Rita Corso, and Alexandra Acco, “Glutathione system in animal model of solid tumors: From regulation to therapeutic target,” Critical Reviews in Oncology/Hematology, 2018. View at Publisher · View at Google Scholar
  • Shimaa A. Abass, Nabil M. Abdel El-Hamid, Tarek K. Abouzed, and Mamdouh Mohammad El-Shishtawy, “Chemosensitizing effect of Alpinia officinarum rhizome extract in cisplatin-treated rats with hepatocellular carcinoma,” Biomedicine & Pharmacotherapy, vol. 101, pp. 710–718, 2018. View at Publisher · View at Google Scholar
  • Philippe Icard, Seth Shulman, Diana Farhat, Jean-Marc Steyaert, Marco Alifano, and Hubert Lincet, “How the Warburg effect supports aggressiveness and drug resistance of cancer cells?,” Drug Resistance Updates, vol. 38, pp. 1–11, 2018. View at Publisher · View at Google Scholar
  • Dunyin Gu, Shereen Tan, Andrea J. O’Connor, and Greg G. Qiao, “On-Demand Cascade Release of Hydrophobic Chemotherapeutics from a Multicomponent Hydrogel System,” ACS Biomaterials Science & Engineering, 2018. View at Publisher · View at Google Scholar
  • Hyeongmin Kim, and Yong-Min Kim, “Pan-cancer analysis of somatic mutations and transcriptomes reveals common functional gene clusters shared by multiple cancer types,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Yue-Xiao Xing, Ming-Hui Li, Liang Tao, Ling-Yu Ruan, Wei Hong, Cheng Chen, Wen-Long Zhao, Han Xu, Jian-Feng Chen, and Jun-Song Wang, “ Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by 1 H NMR Based Metabolic Profiling ,” Journal of Proteome Research, 2018. View at Publisher · View at Google Scholar
  • Anubha Shukla, and Sunil P. Trivedi, “An in vitro analysis of the rat C6 glioma cells to elucidate the Linear alkylbenzene Sulfonate induced oxidative stress and consequent G2/M phase cell cycle arrest and cellular apoptosis,” Chemosphere, 2018. View at Publisher · View at Google Scholar
  • Maciej Serda, Katarzyna Malarz, Jaroslaw Polanski, Anna Mrozek-Wilczkiewicz, Marta Rejmund, and Robert Musiol, “The role of oxidative stress in activity of anticancer thiosemicarbazones,” Oncotarget, vol. 9, no. 25, pp. 17689–17710, 2018. View at Publisher · View at Google Scholar
  • Marcelo Silva, and Maria da Gloria Carvalho, “Detoxification enzymes: cellular metabolism and susceptibility to various diseases,” Revista da Associação Médica Brasileira, vol. 64, no. 4, pp. 307–310, 2018. View at Publisher · View at Google Scholar
  • Ravindran Ankathil, Husin Azlan, Abu Abdullah Dzarr , and Abdul Aziz Baba, “Pharmacogenetics and the treatment of chronic myeloid leukemia: how relevant clinically? An update,” Pharmacogenomics, 2018. View at Publisher · View at Google Scholar
  • Zhaoshi Bai, Meiqi Gao, Xiaobo Xu, Huijuan Zhang, Jingwen Xu, Qi Guan, Qing Wang, Jianan Du, Zhengqiang Li, Daiying Zuo, Weige Zhang, and Yingliang Wu, “Overcoming resistance to mitochondrial apoptosis by BZML-induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells,” Cell Proliferation, pp. e12450, 2018. View at Publisher · View at Google Scholar
  • Jun-Ho Cho, Goo-Young Kim, Brian C. Mansfield, and Janice Y. Chou, “Hepatic glucose-6-phosphatase-α deficiency leads to metabolic reprogramming in glycogen storage disease type Ia,” Biochemical and Biophysical Research Communications, 2018. View at Publisher · View at Google Scholar
  • Xia Sun, Min Liu, Luyao Gao, Ying Mao, Diming Zhao, Jianfeng Zhuang, and Lei Liu, “A novel tetrahydroisoquinoline (THIQ) analogue induces mitochondria-dependent apoptosis,” European Journal of Medicinal Chemistry, 2018. View at Publisher · View at Google Scholar
  • Santhosh Kalash Rajendrakumar, Kondareddy Cherukula, Hyeong Ju Park, Saji Uthaman, Yong Yeon Jeong, Byeong-Il Lee, and In-Kyu Park, “Dual-stimuli-responsive albumin-polyplex nanoassembly for spatially controlled gene release in metastatic breast cancer,” Journal of Controlled Release, 2018. View at Publisher · View at Google Scholar
  • Anna Chiara Nittoli, Susan Costantini, Angela Sorice, Francesca Capone, Roberto Ciarcia, Stefania Marzocco, Alfredo Budillon, and Lorella Severino, “Effects of α-zearalenol on the metabolome of two breast cancer cell lines by 1H-NMR approach,” Metabolomics, vol. 14, no. 3, 2018. View at Publisher · View at Google Scholar
  • Tanveer Sharif, Emma Martell, Cathleen Dai, Mohammad Saleh Ghassemi-Rad, Barry E. Kennedy, Patrick W.K. Lee, and Shashi Gujar, “ Regulation of Cancer and Cancer-Related Genes via NAD + ,” Antioxidants & Redox Signaling, 2018. View at Publisher · View at Google Scholar
  • G.A. Nagana Gowda, Richard Berg, Howard H. Yang, Maxwell P. Lee, Olufunmilayo F. Olopade, Daniel Raftery, Fariba Tayyari, Suresh K. Mittal, Sulma I. Mohammed, and Wilfred F. Ngwa, “Metabolic profiles of triple-negative and luminal A breast cancer subtypes in African-American identify key metabolic differences,” Oncotarget, vol. 9, no. 14, pp. 11677–11690, 2018. View at Publisher · View at Google Scholar
  • Yu-Guo Yuan, Shimin Zhang, Ji-Yoon Hwang, and Il-Keun Kong, “Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells,” Oxidative Medicine and Cellular Longevity, vol. 2018, pp. 1–21, 2018. View at Publisher · View at Google Scholar
  • Artur Beberok, Zuzanna Rzepka, Michalina Respondek, Jakub Rok, Michał Stradowski, and Dorota Wrześniok, “Moxifloxacin as an inducer of apoptosis in melanoma cells: A study at the cellular and molecular level,” Toxicology in Vitro, 2018. View at Publisher · View at Google Scholar
  • Yi-Yang Peng, Diana Diaz-Dussan, Piyush Kumar, and Ravin Narain, “Tumor Microenvironment-Regulated Redox Responsive Cationic Galactose-Based Hyperbranched Polymers for siRNA Delivery,” Bioconjugate Chemistry, 2018. View at Publisher · View at Google Scholar
  • Chang Liu, Depeng Wang, Ye Zhan, Lingyue Yan, Qian Lu, Michael Yu Zarng Chang, Jingwen Luo, Lidai Wang, Dan Du, Yuehe Lin, Jun Xia, and Yun Wu, “ Switchable Photoacoustic Imaging of Glutathione Using MnO 2 Nanotubes for Cancer Diagnosis ,” ACS Applied Materials & Interfaces, 2018. View at Publisher · View at Google Scholar
  • Malgorzata Kucinska, Helena Mieszczak, Hanna Piotrowska-Kempisty, Mariusz Kaczmarek, Walter Granig, Marek Murias, and Thomas Erker, “The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines,” Investigational New Drugs, 2018. View at Publisher · View at Google Scholar
  • M. Matuszewski, B. Szymańska, A. Długosz, B. Małkiewicz, J. Dembowski, and A. Piwowar, “Preliminary Evaluation of the Diagnostic Usefulness of Uroplakin 2 with an Assessment of the Antioxidant Potential of Patients with Bladder Cancer,” BioMed Research International, vol. 2018, pp. 1–9, 2018. View at Publisher · View at Google Scholar
  • Ana S. Nunes, Elisabete C. Costa, Andreia S. Barros, Duarte de Melo-Diogo, and Ilídio J. Correia, “Establishment of 2D Cell Cultures Derived From 3D MCF-7 Spheroids Displaying a Doxorubicin Resistant Profile,” Biotechnology Journal, pp. 1800268, 2018. View at Publisher · View at Google Scholar
  • Lorena García-Hevia, Manuel Bañobre-López, and Juan Gallo, “Recent Progress on Manganese-Based Nanostructures as Responsive MRI Contrast Agents,” Chemistry - A European Journal, 2018. View at Publisher · View at Google Scholar
  • Ying Chen, Ming Han, Akiko Matsumoto, Yewei Wang, David C. Thompson, and Vasilis Vasiliou, “Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis,” Alcohol and Cancer, vol. 1032, pp. 37–53, 2018. View at Publisher · View at Google Scholar
  • Maria C. Arno, Rebecca J. Williams, Panagiotis Bexis, Anaïs Pitto-Barry, Nigel Kirby, Andrew P. Dove, and Rachel K. O'Reilly, “Exploiting topology-directed nanoparticle disassembly for triggered drug delivery,” Biomaterials, vol. 180, pp. 184–192, 2018. View at Publisher · View at Google Scholar
  • Tadhg J. P. McGivern, Creina Slator, Andrew Kellett, and Celine J. Marmion, “Innovative DNA-Targeted Metallo-prodrug Strategy Combining Histone Deacetylase Inhibition with Oxidative Stress,” Molecular Pharmaceutics, 2018. View at Publisher · View at Google Scholar
  • Heting Hou, Dong Zhang, Jiewen Lin, Yingying Zhang, Chengyong Li, Zhe Wang, Jiaoyan Ren, Maojin Yao, Ka-hing Wong, and Yi Wang, “Zein-Paclitaxel Prodrug Nanoparticles for Redox-Triggered Drug Delivery and Enhanced Therapeutic Efficiency,” Journal of Agricultural and Food Chemistry, 2018. View at Publisher · View at Google Scholar
  • Feng Jin, Yuyang Jiang, Ning Wang, Bin Zhang, Dan Gao, Feng Liu, and Hongxia Liu, “Combing metabolomics with bioanalysis methods to study the antitumor mechanism of the new acridone derivative 8q on CCRF-CEM cells: 8q induced mitochondrial-mediated apoptosis and targeted the PI3K/AKT/FOXO1 pathway,” Journal of Pharmaceutical and Biomedical Analysis, vol. 160, pp. 314–322, 2018. View at Publisher · View at Google Scholar
  • Rohan Moniruzzaman, Mati Ur Rehman, Qing-Li Zhao, Paras Jawaid, Yohei Mitsuhashi, Shuichi Imaue, Kumiko Fujiwara, Ryohei Ogawa, Kei Tomihara, Jun-ichi Saitoh, Kyo Noguchi, Takashi Kondo, and Makoto Noguchi, “Roles of intracellular and extracellular ROS formation in apoptosis induced by cold atmospheric helium plasma and X-irradiation in the presence of sulfasalazine,” Free Radical Biology and Medicine, 2018. View at Publisher · View at Google Scholar
  • Roberto C. Burini, Hugo T. Kano, and Yong-Ming Yu, “The Life Evolution on the Sulfur Cycle: From Ancient Elemental Sulfur Reduction and Sulfide Oxidation to the Contemporary Thiol-Redox Challenges,” Glutathione in Health and Disease, 2018. View at Publisher · View at Google Scholar
  • Pinar Erkekoglu, “Introductory Chapter: A General Overview of Glutathione, Glutathione Transport, and Glutathione Applications,” Glutathione in Health and Disease, 2018. View at Publisher · View at Google Scholar
  • Claudia Bottone, Rosa Camerlingo, Roberta Miceli, Giovanna Salbitani, Giuseppe Sessa, Giuseppe Pirozzi, and Simona Carfagna, “ Antioxidant and anti-proliferative properties of extracts from heterotrophic cultures of Galdieria sulphuraria ,” Natural Product Research, pp. 1–5, 2018. View at Publisher · View at Google Scholar
  • Weipeng Hong, Peiheng Cai, Chuncao Xu, Di Cao, Weibang Yu, Zhongxiang Zhao, Min Huang, and Jing Jin, “Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System,” Frontiers in Pharmacology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Youngsoo Jun, So-Yeon Park, Ji-Young Kim, and Jeong-Seok Nam, “Strategies to tackle radiation resistance by penetrating cancer stem cell line of scrimmage,” Recent Patents on Anti-Cancer Drug Discovery, vol. 13, no. 1, pp. 18–39, 2018. View at Publisher · View at Google Scholar
  • Karolina Tecza, Ewa Grzybowska, Jolanta Pamula-Pilat, Joanna Lanuszewska, and Dorota Butkiewicz, “Pharmacogenetics of toxicity of 5-fluorouracil, doxorubicin and cyclophosphamide chemotherapy in breast cancer patients,” Oncotarget, vol. 9, no. 10, pp. 9114–9136, 2018. View at Publisher · View at Google Scholar
  • Narjis Hadi Al-Saadi, and Zahraa Hassan Ali, “Antioxidants and lipids peroxidation status in patients with colon cancer,” International Journal of Engineering and Technology(UAE), vol. 7, no. 4, pp. 110–113, 2018. View at Publisher · View at Google Scholar
  • Hiroto Hatakeyama, Takuya Fujiwara, Hiromi Sato, Ayu Terui, and Akihiro Hisaka, “Investigation of Metabolomic Changes in Sunitinib-Resistant Human Renal Carcinoma 786-O Cells by Capillary Electrophoresis-Time of Flight Mass Spectrometry,” Biological and Pharmaceutical Bulletin, vol. 41, no. 4, pp. 619–627, 2018. View at Publisher · View at Google Scholar
  • Ching-Hsuan Tung, and Weiqi Zhang, “Redox-responsive cisplatin nanogels for anticancer drug delivery,” Chemical Communications, vol. 54, no. 60, pp. 8367–8370, 2018. View at Publisher · View at Google Scholar
  • Dongin Kim, Chang-Hee Whang, Eunsoo Yoo, Seong Kwon Hur, Kyeong Soo Kim, and Seongbong Jo, “A highly GSH-sensitive SN-38 prodrug with an “OFF-to-ON” fluorescence switch as a bifunctional anticancer agent,” Chemical Communications, vol. 54, no. 65, pp. 9031–9034, 2018. View at Publisher · View at Google Scholar
  • Santanu Panja, Sumit Ghosh, and Kumaresh Ghosh, “Pyridine/pyridinium symmetrical bisamides as functional materials: aggregation, selective sensing and drug release,” New Journal of Chemistry, 2018. View at Publisher · View at Google Scholar
  • Pierpaola Davalli, Gaetano Marverti, Angela Lauriola, and Domenico D’Arca, “Targeting Oxidatively Induced DNA Damage Response in Cancer: Opportunities for Novel Cancer Therapies,” Oxidative Medicine and Cellular Longevity, vol. 2018, pp. 1–21, 2018. View at Publisher · View at Google Scholar
  • Lisha Xiang, and Gregg L. Semenza, “Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy,” Advances in Cancer Research, 2018. View at Publisher · View at Google Scholar
  • Arvind Parmar, David Zahra, Guo Jun Liu, Nigel Lengkeek, Federica Saletta, Arnaud Charil, Maria Kavallaris, Orazio Vittorio, Giancarlo Pascali, Florida Voli, Eugene Yee, Kathleen Kimpton, Giuseppe Cirillo, Andrew Arthur, Gita Rahardjo, Luigi Lerra, and Aria Ahmed-Cox, “In vivo [64Cu]CuCl2 PET imaging reveals activity of dextran-Catechin on tumor copper homeostasis,” Theranostics, vol. 8, no. 20, pp. 5645–5659, 2018. View at Publisher · View at Google Scholar
  • Lidia de Bari, Anna Atlante, Tatiana Armeni, and Miklòs Péter Kalapos, “Synthesis and metabolism of methylglyoxal, S-D-lactoylglutathione and D-lactate in cancer and Alzheimer's disease. Exploring the crossroad of eternal youth and premature aging,” Ageing Research Reviews, pp. 100915, 2019. View at Publisher · View at Google Scholar
  • Huanhuan Lv, Chenxiao Zhen, Junyu Liu, Pengfei Yang, Lijiang Hu, and Peng Shang, “Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy,” Oxidative Medicine and Cellular Longevity, vol. 2019, pp. 1–16, 2019. View at Publisher · View at Google Scholar
  • Aradhana Rani, Justin Stebbing, Georgios Giamas, and John Murphy, “Endocrine Resistance in Hormone Receptor Positive Breast Cancer–From Mechanism to Therapy,” Frontiers in Endocrinology, vol. 10, 2019. View at Publisher · View at Google Scholar
  • Joseph A. Combs, and Gina M. DeNicola, “The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival,” Cancers, vol. 11, no. 5, pp. 678, 2019. View at Publisher · View at Google Scholar
  • Susi Tan, Atsushi Yamashita, Shu Jun Gao, and Motoichi Kurisawa, “Hyaluronic acid hydrogels with defined crosslink density for the efficient enrichment of breast cancer stem cells,” Acta Biomaterialia, 2019. View at Publisher · View at Google Scholar
  • Behrouz Hassannia, Peter Vandenabeele, and Tom Vanden Berghe, “Targeting Ferroptosis to Iron Out Cancer,” Cancer Cell, 2019. View at Publisher · View at Google Scholar
  • Prahlad V. Raninga, Andy C. Lee, Debottam Sinha, Yu‐Yin Shih, Deepak Mittal, Ashwini Makhale, Amanda L. Bain, Devathri Nanayakarra, Kathryn F. Tonissen, Murugan Kalimutho, and Kum Kum Khanna, “Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti‐PD‐L1 antibody for treatment of triple‐negative breast cancer,” International Journal of Cancer, 2019. View at Publisher · View at Google Scholar
  • Tanweer Haider, Rahul Tiwari, Suresh Prasad Vyas, and Vandana Soni, “Molecular Determinants as Therapeutic Targets in Cancer Chemotherapy: An Update,” Pharmacology & Therapeutics, 2019. View at Publisher · View at Google Scholar
  • Filipe J. Teixeira, Heitor O. Santos, Scott L. Howell, and Gustavo D. Pimentel, “Whey Protein in Cancer Therapy: A Narrative Review,” Pharmacological Research, 2019. View at Publisher · View at Google Scholar
  • Yi-Cheng Gao, Xiong-Hui Zhou, and Wen Zhang, “An Ensemble Strategy to Predict Prognosis in Ovarian Cancer Based on Gene Modules,” Frontiers in Genetics, vol. 10, 2019. View at Publisher · View at Google Scholar
  • Ilaria Granata, Enrico Troiano, Mara Sangiovanni, and Mario Rosario Guarracino, “Integration of transcriptomic data in a genome-scale metabolic model to investigate the link between obesity and breast cancer,” BMC Bioinformatics, vol. 20, no. S4, 2019. View at Publisher · View at Google Scholar
  • Zhivko Zhelev, Ekaterina Georgieva, Dessislava Lazarova, Severina Semkova, Ichio Aoki, Maya Gulubova, Tatsuya Higashi, and Rumiana Bakalova, ““Redox Imaging” to Distinguish Cells with Different Proliferative Indexes: Superoxide, Hydroperoxides, and Their Ratio as Potential Biomarkers,” Oxidative Medicine and Cellular Longevity, vol. 2019, pp. 1–18, 2019. View at Publisher · View at Google Scholar
  • Madalina Andreea Badea, Mihaela Balas, Anca Hermenean, Alina Ciceu, Hildegard Herman, Daniela Ionita, and Anca Dinischiotu, “Influence of Matrigel on Single- and Multiple-Spheroid Cultures in Breast Cancer Research,” SLAS DISCOVERY: Advancing Life Sciences R&D, pp. 247255521983469, 2019. View at Publisher · View at Google Scholar
  • Entaz Bahar, Ji-Ye Kim, and Hyonok Yoon, “Chemotherapy Resistance Explained through Endoplasmic Reticulum Stress-Dependent Signaling,” Cancers, vol. 11, no. 3, pp. 338, 2019. View at Publisher · View at Google Scholar
  • Claire Gourzones, Céline Bellanger, Sylvain Lamure, Ouissem Gadacha, Elvira De Paco, Laure Vincent, Guillaume Cartron, Bernard Klein, and Jérôme Moreaux, “Antioxidant Defenses Confer Resistance to High Dose Melphalan in Multiple Myeloma Cells,” Cancers, vol. 11, no. 4, pp. 439, 2019. View at Publisher · View at Google Scholar
  • María Jesús Ramírez-Expósito, and José Manuel Martínez-Martos, “The Delicate Equilibrium between Oxidants and Antioxidants in Brain Glioma,” Current Neuropharmacology, vol. 17, no. 4, pp. 342–351, 2019. View at Publisher · View at Google Scholar
  • K. A. Alekseeva, D. I. Pisarev, A. Yu. Malyutina, E. T. Zhilyakova, Z. E. Tsvetkova, and Yu. A. Polkovnikova, “Working Out Quality Standards Of Model Composition Samples Of Granulated Dosage Form With Glutathione Restored,” Pharmacy & Pharmacology, vol. 7, no. 1, pp. 13–19, 2019. View at Publisher · View at Google Scholar
  • Ahmed E.M. Elhassanny, Daniel A. Ladin, Eman Soliman, Hussam Albassam, Andrew Morris, Robert Kobet, Kathleen Thayne, Colin Burns, Allison S. Danell, and Rukiyah Van Dross, “Prostaglandin D2-ethanolamide induces skin cancer apoptosis by suppressing the activity of cellular antioxidants,” Prostaglandins & Other Lipid Mediators, 2019. View at Publisher · View at Google Scholar
  • Kateřina Macáková, Maria Carmen Catapano, Kateřina Klimková, Přemysl Mladěnka, Václav Tvrdý, and Jana Karlíčková, “Hematoxylin assay of cupric chelation can give false positive results,” Journal of Trace Elements in Medicine and Biology, vol. 52, pp. 29–36, 2019. View at Publisher · View at Google Scholar
  • Desiree Linda Fraser, Barend Andre Stander, and Vanessa Steenkamp, “Cytotoxic activity of pentachlorophenol and its active metabolites in SH-SY5Y neuroblastoma cells,” Toxicology in Vitro, 2019. View at Publisher · View at Google Scholar
  • Yangmei Chen, Shibing Xiong, Fenghua Zhao, Xugang Lu, Boyao Wu, and Bangcheng Yang, “Effect of magnesium on reducing the UV-induced oxidative damage in marrow mesenchymal stem cells,” Journal of Biomedical Materials Research Part A, 2019. View at Publisher · View at Google Scholar
  • Hui Wang, Heng Jiang, Cyril Corbet, Sven de Mey, Kalun Law, Thierry Gevaert, Olivier Feron, and Mark De Ridder, “Piperlongumine increases sensitivity of colorectal cancer cells to radiation: involvement of ROS production via dual inhibition of glutathione and thioredoxin systems,” Cancer Letters, 2019. View at Publisher · View at Google Scholar
  • Lisha Xiang, Jun Mou, Bin Shao, Yuquan Wei, Houjie Liang, Naoharu Takano, Gregg L. Semenza, and Ganfeng Xie, “Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization,” Cell Death & Disease, vol. 10, no. 2, 2019. View at Publisher · View at Google Scholar
  • Shu Qing Wang, Yang Xiang Yu, Shu Xiang Cui, Zu Hua Gao, and Xian Jun Qu, “Heterozygous knockout insulin-like growth factor-1 receptor (IGF-1R) regulates mitochondrial functions and prevents colitis and colorectal cancer,” Free Radical Biology and Medicine, 2019. View at Publisher · View at Google Scholar
  • Omnia Safwat, Rania Nagi Abd-Ellatif, Tarek Soliman Othman, Mohamed Afifi, and Mohammed El-Magd, “The evolving role of protein disulfide isomerase A3 in Egyptian bladder cancer patients,” Gene, 2019. View at Publisher · View at Google Scholar
  • Nimisha Singh, Fadoua Sallem, Celine Mirjolet, Thomas Nury, Suban Kumar Sahoo, Nadine Millot, and Rajender Kumar, “Polydopamine Modified Superparamagnetic Iron Oxide Nanoparticles as Multifunctional Nanocarrier for Targeted Prostate Cancer Treatment,” Nanomaterials, vol. 9, no. 2, pp. 138, 2019. View at Publisher · View at Google Scholar
  • Rabiatul Basria S.M.N. Mydin, and Simon I. Okekpa, “Reactive Oxygen Species, Cellular Redox Homeostasis and Cancer,” Homeostasis - An Integrated Vision, 2019. View at Publisher · View at Google Scholar
  • Bo Song, Wenjing Shi, Wenbo Shi, Xiaodan Qin, Hua Ma, Mingqian Tan, Wenzhu Zhang, Lianying Guo, and Jingli Yuan, “ A dual-modal nanoprobe based on Eu( iii ) complex–MnO 2 nanosheet nanocomposites for time-gated luminescence–magnetic resonance imaging of glutathione in vitro and in vivo ,” Nanoscale, 2019. View at Publisher · View at Google Scholar