Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2013, Article ID 980374, 6 pages
http://dx.doi.org/10.1155/2013/980374
Review Article

Protective Role of Melatonin in Neonatal Diseases

1Neonatal Intensive Care Unit, Department of Pediatrics, University of Messina, Via Consolare Valeria, 98125 Messina, Italy
2Unit of Pediatric Genetics and Immunology, Department of Pediatrics, University of Messina, Via Consolare Valeria 1, 98125 Messina, Italy
3Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 40729, USA

Received 27 September 2013; Accepted 7 November 2013

Academic Editor: Serafina Perrone

Copyright © 2013 Eloisa Gitto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Halliwell, “Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?” The Lancet, vol. 344, no. 8924, pp. 721–724, 1994. View at Publisher · View at Google Scholar · View at Scopus
  2. I. Fridovich, “Oxygen toxicity: a radical explanation,” Journal of Experimental Biology, vol. 201, no. 8, pp. 1203–1209, 1998. View at Google Scholar · View at Scopus
  3. S. Perrone, M. L. Tataranno, S. Negro et al., “Early identification of the risk for free radical-related diseases in preterm newborns,” Early Human Development, vol. 86, no. 4, pp. 241–244, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. E. Gitto, R. J. Reiter, M. Karbownik et al., “Causes of oxidative stress in the pre- and perinatal period,” Biology of the Neonate, vol. 81, no. 3, pp. 146–157, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. O. D. Saugstad, “Bronchopulmonary dysplasia: oxidative stress and antioxidants,” Seminars in Neonatology, vol. 8, no. 1, pp. 39–49, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. O. D. Saugstad, “Oxidative stress in the newborn: a 30-year perspective,” Biology of the Neonate, vol. 88, no. 3, pp. 228–236, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. O. D. Saugstad, “Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production,” Pediatric Research, vol. 23, no. 2, pp. 143–150, 1988. View at Google Scholar · View at Scopus
  8. R. L. Haynes, R. D. Folkerth, R. J. Keefe et al., “Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia,” Journal of Neuropathology and Experimental Neurology, vol. 62, no. 5, pp. 441–450, 2003. View at Google Scholar · View at Scopus
  9. R. I. Clyman, O. D. Saugstad, and F. Mauray, “Reactive oxygen metabolites relax the lamb ductus arteriosus by stimulating prostaglandin production,” Circulation Research, vol. 64, no. 1, pp. 1–8, 1989. View at Google Scholar · View at Scopus
  10. S. L. Archer, D. Peterson, D. P. Nelson et al., “Oxygen radicals and antioxidant enzymes alter pulmonary vascular reactivity in the rat lung,” Journal of Applied Physiology, vol. 66, no. 1, pp. 102–111, 1989. View at Google Scholar · View at Scopus
  11. J. Sanderud, K. Bjoro, and O. D. Saugstad, “Oxygen radicals stimulate thromboxane and prostacyclin synthesis and induce vasoconstriction in pig lungs,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 53, no. 5, pp. 447–455, 1993. View at Google Scholar · View at Scopus
  12. R. J. Reiter, S. D. Paredes, L. C. Manchester, and D.-X. Tan, “Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin melatonin as an antioxidant,” Critical Reviews in Biochemistry and Molecular Biology, vol. 44, no. 4, pp. 175–200, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. R. J. Reiter, D.-X. Tan, and L. Fuentes-Broto, “Melatonin: a multitasking molecule,” Progress in brain research, vol. 181, pp. 127–151, 2010. View at Google Scholar · View at Scopus
  14. A. Brzezinski, “Melatonin in humans,” The New England Journal of Medicine, vol. 336, no. 3, pp. 186–195, 1997. View at Publisher · View at Google Scholar · View at Scopus
  15. R. J. Reiter, D.-X. Tan, C. Osuna, and E. Gitto, “Actions of melatonin in the reduction of oxidative stress: a review,” Journal of Biomedical Science, vol. 7, no. 6, pp. 444–458, 2000. View at Google Scholar · View at Scopus
  16. R. J. Reiter, D.-X. Tan, M. P. Terron, L. J. Flores, and Z. Czarnocki, “Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions,” Acta Biochimica Polonica, vol. 54, no. 1, pp. 1–9, 2007. View at Google Scholar · View at Scopus
  17. N. Mohan, K. Sadeghi, R. J. Reiter, and M. L. Meltz, “The neurohormone melatonin inhibits cytokine, mitogen and ionizing radiation induced NF-κB,” Biochemistry and Molecular Biology International, vol. 37, no. 6, pp. 1063–1070, 1995. View at Google Scholar · View at Scopus
  18. J. C. Mayo, R. M. Sainz, D.-X. Tan et al., “Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages,” Journal of Neuroimmunology, vol. 165, no. 1-2, pp. 139–149, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Marseglia, S. Aversa, I. Barberi et al., “High endogenous melatonin levels in critically ill children: a pilot study,” Journal of Pediatrics, vol. 62, pp. 357–360, 2013. View at Google Scholar
  20. B. Poeggeler, “Melatonin replacement therapy infants: the impact of pharmacokinetics,” Expert Review of Clinical Pharmacology, vol. 6, pp. 367–368, 2013. View at Google Scholar
  21. N. M. Merchant, D. V. Azzopardi, A. F. Hawwa et al., “Pharmacokinetics of melatonin in preterm infants,” British Journal of Clinical Pharmacology, vol. 76, pp. 725–733, 2013. View at Google Scholar
  22. Z. S. Vexler and D. M. Ferriero, “Molecular and biochemical mechanisms of perinatal brain injury,” Seminars in Neonatology, vol. 6, no. 2, pp. 99–108, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Lekic, A. Manaenko, W. Rolland et al., “Neuroprotection by melatonin after germinal matrix hemorrhage in neonatal rats,” Acta Neurochirurgica, no. 111, pp. 201–206, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. T. E. Inder and J. J. Volpe, “Mechanisms of perinatal brain injury,” Seminars in Neonatology, vol. 5, no. 1, pp. 3–16, 2000. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Y. Yager and J. A. Thornhill, “The effect of age on susceptibility to hypoxic-ischemic brain damage,” Neuroscience and Biobehavioral Reviews, vol. 21, no. 2, pp. 167–174, 1997. View at Publisher · View at Google Scholar · View at Scopus
  26. A. J. du Plessis and J. J. Volpe, “Perinatal brain injury in the preterm and term newborn,” Current Opinion in Neurology, vol. 15, no. 2, pp. 151–157, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Perrone, L. M. Tataranno, G. Stazzoni et al., “Brain susceptibility to oxidative stress in the perinatal period,” Journal of Maternal-Fetal and Neonatal Medicine. In press.
  28. P. A. Vitte, C. Harthe, P. Lestage, B. Claustrat, and P. Bobillier, “Plasma, cerebrospinal fluid, and brain distribution of 14C-melatonin in rat: a biochemical and autoradiographic study,” Journal of Pineal Research, vol. 5, no. 5, pp. 437–453, 1988. View at Google Scholar · View at Scopus
  29. A. Menendez-Pelaez and R. J. Reiter, “Distribution of melatonin in mammalian tissues: the relative importance of nuclear versus cytosolic localization,” Journal of Pineal Research, vol. 15, no. 2, pp. 59–69, 1993. View at Google Scholar · View at Scopus
  30. Y. K. Gupta, M. Gupta, and K. Kohli, “Neuroprotective role of melatonin in oxidative stress vulnerable brain,” Indian Journal of Physiology and Pharmacology, vol. 47, no. 4, pp. 373–386, 2003. View at Google Scholar · View at Scopus
  31. S. Perrone, G. Stazzoni, M. L. Tataranno, and G. Buonocore, “New pharmacologic and therapeutic approaches for hypoxic-ischemic encephalopathy in the newborn,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 25, no. 1, pp. 83–88, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. S. L. Miller, E. B. Yan, M. Castillo-Meléndez, G. Jenkin, and D. W. Walker, “Melatonin provides neuroprotection in the late-gestation fetal sheep brain in response to umbilical cord occlusion,” Developmental Neuroscience, vol. 27, no. 2–4, pp. 200–210, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. A.-K. Welin, P. Svedin, R. Lapatto et al., “Melatonin reduces inflammation and cell death in white matter in the mid-gestation fetal sheep following umbilical cord occlusion,” Pediatric Research, vol. 61, no. 2, pp. 153–158, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. I. Husson, B. Mespls, P. Bac, J. Vamecq, P. Evrard, and P. Gressens, “Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge,” Annals of Neurology, vol. 51, no. 1, pp. 82–92, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. F. Fulia, E. Gitto, S. Cuzzocrea et al., “Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin,” Journal of Pineal Research, vol. 31, no. 4, pp. 343–349, 2001. View at Publisher · View at Google Scholar · View at Scopus
  36. N. J. Robertson, S. Faulkner, B. Fleiss et al., “Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model,” Brain, vol. 136, pp. 90–105, 2013. View at Google Scholar
  37. Y. Okatani, K. Okamoto, K. Hayashi, A. Wakatsuki, S. Tamura, and Y. Sagara, “Maternal-fetal transfer of melatonin in pregnant women near term,” Journal of Pineal Research, vol. 25, no. 3, pp. 129–134, 1998. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Perrone, M. L. Tataranno, and G. Buonocore, “Oxidative stress and bronchopulmonary dysplasia,” Journal of Clinical Neonatology, vol. 1, pp. 109–114, 2012. View at Google Scholar
  39. O. D. Saugstad, “Chronic lung disease: the role of oxidative stress,” Biology of the Neonate, vol. 74, supplement 1, pp. 21–28, 1998. View at Publisher · View at Google Scholar · View at Scopus
  40. L. Pan, J.-H. Fu, X.-D. Xue, W. Xu, P. Zhou, and B. Wei, “Melatonin protects against oxidative damage in a neonatal rat model of bronchopulmonary dysplasia,” World Journal of Pediatrics, vol. 5, no. 3, pp. 216–221, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. E. Gitto, R. J. Reiter, G. Sabatino et al., “Correlation among cytokines, bronchopulmonary dysplasia and modality of ventilation in preterm newborns: improvement with melatonin treatment,” Journal of Pineal Research, vol. 39, no. 3, pp. 287–293, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. R. J. Reiter, D.-X. Tan, L. C. Manchester, S. Lopez-Burillo, R. M. Sainz, and J. C. Mayo, “Melatonin: detoxification of oxygen and nitrogen-based toxic reactants,” Advances in Experimental Medicine and Biology, vol. 527, pp. 539–548, 2003. View at Google Scholar · View at Scopus
  43. B. Al Qadi-Nassar, F. Bichon-Laurent, K. Portet, P. Tramini, B. Arnoux, and A. Michel, “Effects of L-arginine and phosphodiesterase-5 inhibitor, sildenafil, on inflammation and airway responsiveness of sensitized BP2 mice,” Fundamental and Clinical Pharmacology, vol. 21, no. 6, pp. 611–620, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. H.-C. Sun, X.-M. Qian, S.-N. Nie, and X.-H. Wu, “Serial analysis of gene expression in mice with lipopolysaccharide-induced acute lung injury,” Chinese Journal of Traumatology, vol. 8, no. 2, pp. 67–73, 2005. View at Google Scholar · View at Scopus
  45. J. Neu and W. A. Walker, “Necrotizing enterocolitis,” The New England Journal of Medicine, vol. 364, no. 3, pp. 255–264, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. A. Guven, B. Uysal, G. Gundogdu, E. Oztas, H. Ozturk, and A. Korkmaz, “Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model,” Journal of Pediatric Surgery, vol. 46, no. 11, pp. 2101–2107, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. C. J. Stewart, E. C. L. Marrs, A. Nelson et al., “Development of the preterm gut microbiome in twins at risk of necrotising enterocolitis and sepsis,” PLoS ONE, vol. 8, Article ID e73465, 2013. View at Google Scholar
  48. Y.-C. Chen, Y.-L. Tain, J.-M. Sheen, and L.-T. Huang, “Melatonin utility in neonates and children,” Journal of the Formosan Medical Association, vol. 111, no. 2, pp. 57–66, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. S. Perrone, M. L. Tataranno, S. Negro et al., “May oxidative stress biomarkers in cord blood predict the occurrence of necrotizing enterocolitis in preterm infants?” Journal of Maternal-Fetal and Neonatal Medicine, vol. 25, supplement 1, pp. 128–131, 2012. View at Publisher · View at Google Scholar · View at Scopus
  50. F. Çekmez, M. Çetinkaya, C. Tayman et al., “Evaluation of melatonin and prostaglandin E1 combination on necrotizing enterocolitis model in neonatal rats,” Regulatory Peptides, vol. 184, pp. 121–125, 2013. View at Google Scholar
  51. S. Perrone, P. Vezzosi, M. Longini et al., “Biomarkers of oxidative stress in babies at high risk for retinopathy of prematurity,” Frontiers in Bioscience, vol. 1, pp. 547–552, 2009. View at Google Scholar · View at Scopus
  52. N. Ashton and C. Cook, “Direct observation of the effect of oxygen on developing vessels: preliminary report,” British Journal of Ophthalmology, vol. 38, pp. 433–440, 1954. View at Google Scholar
  53. W. A. Silverman, “Retinopathy of prematurity: oxygen dogma challenged,” Archives of Disease in Childhood, vol. 57, no. 10, pp. 731–733, 1982. View at Google Scholar · View at Scopus
  54. J. M. Di Fiore, J. N. Bloom, F. Orge et al., “A higher incidence of intermittent hypoxemic episodes is associated with severe retinopathy of prematurity,” Journal of Pediatrics, vol. 157, no. 1, pp. 69–73, 2010. View at Publisher · View at Google Scholar · View at Scopus
  55. C. Kaur, V. Sivakumar, R. Robinson et al., “Neuroprotective effect of melatonin against hypoxia-induced retinal ganglion cell death in neonatal rats,” Journal of Pineal Research, vol. 54, pp. 190–206, 2013. View at Google Scholar
  56. A. W. Siu, M. Maldonado, M. Sanchez-Hidalgo, D.-X. Tan, and R. J. Reiter, “Protective effects of melatonin in experimental free radical-related ocular diseases,” Journal of Pineal Research, vol. 40, no. 2, pp. 101–109, 2006. View at Publisher · View at Google Scholar · View at Scopus
  57. H. Huang, Z. Wang, S. J. Weng et al., “Neuromodulatory role of melatonin in retinal information processing,” Progress in Retinal and Eye Research, vol. 32, pp. 64–87, 2013. View at Google Scholar
  58. S. W. Park, H. S. Lee, M. S. Lung, and S. J. Kim, “The effect of melatonin on retinal ganglion cell survival in ischemic retina,” Chonnam Medical Journal, vol. 48, pp. 116–122, 2012. View at Google Scholar