Cardioprotection against Ischemia/Reperfusion by Licochalcone B in Isolated Rat Hearts
Table 1
Effect of licochalcone B on cardiac function in rats subjected to I/R (values are means with their standard deviation, ).
Physical index
Reperfusion (%)
15 min
30 min
45 min
LVDP
Control
96.31 ± 3.27
94.45 ± 4.12
93.67 ± 4.92
I/R
40.50 ± 4.59##
47.18 ± 4.08##
48.76 ± 5.88##
0.5 μg/mL licochalcone B
79.76 ± 2.06**
78.28 ± 3.79**
74.13 ± 5.39**
1 μg/mL licochalcone B
85.39 ± 2.73**
82.23 ± 2.83**
81.49 ± 3.41**
3 μg/mL licochalcone B
63.88 ± 5.54*
57.46 ± 3.99*
55.16 ± 2.53*
5 μg/mL licochalcone B
58.54 ± 3.97
52.96 ± 3.82
51.10 ± 4.28
Control
117.68 ± 2.59
116.79 ± 3.63
113.03 ± 3.71
I/R
42.26 ± 3.27##
52.83 ± 3.41##
52.62 ± 3.92##
0.5 μg/mL licochalcone B
68.48 ± 4.84*
75.29 ± 7.46*
74.59 ± 4.40*
1 μg/mL licochalcone B
95.11 ± 3.50**
95.76 ± 1.84**
92.27 ± 2.94**
3 μg/mL licochalcone B
61.05 ± 4.83*
60.36 ± 4.50*
57.68 ± 3.66*
5 μg/mL licochalcone B
55.90 ± 3.60*
55.09 ± 2.10*
54.22 ± 3.97*
Control
102.69 ± 3.72
99.30 ± 4.93
97.35 ± 5.01
I/R
49.22 ± 5.88##
56.47 ± 3.28##
56.05 ± 4.49##
0.5 μg/mL licochalcone B
72.96 ± 5.38*
74.12 ± 2.42*
66.78 ± 5.68*
1 μg/mL licochalcone B
85.60 ± 2.40**
83.62 ± 5.14**
84.76 ± 7.00**
3 μg/mL licochalcone B
54.59 ± 6.85*
53.50 ± 5.25*
50.12 ± 5.55*
5 μg/mL licochalcone B
49.80 ± 4.91
48.27 ± 2.96
47.90 ± 4.25
CF
Control
107.34 ± 3.16
107.09 ± 3.53
104.18 ± 5.97
I/R
90.57 ± 8.78#
100.72 ± 7.65#
99.92 ± 10.00#
0.5 μg/mL licochalcone B
98.83 ± 1.78
98.72 ± 4.89
99.99 ± 3.45
1 μg/mL licochalcone B
95.52 ± 6.18
97.95 ± 5.91
98.22 ± 7.16
3 μg/mL licochalcone B
85.84 ± 3.91*
90.73 ± 8.34*
92.49 ± 7.77*
5 μg/mL licochalcone B
89.78 ± 5.44*
90.07 ± 7.32*
91.88 ± 3.67*
HR
Control
118.13 ± 8.05
118.96 ± 3.81
122.56 ± 3.91
I/R
86.49 ± 10.97##
78.49 ± 8.81##
69.00 ± 3.50##
0.5 μg/mL licochalcone B
94.99 ± 8.90
93.01 ± 11.05*
86.99 ± 1.34*
1 μg/mL licochalcone B
105.46 ± 8.29*
100.55 ± 9.07**
97.07 ± 4.36**
3 μg/mL licochalcone B
97.86 ± 8.53
89.68 ± 6.47
86.47 ± 5.02
5 μg/mL licochalcone B
87.00 ± 9.40
80.49 ± 8.98
74.13 ± 3.57
Left ventricular developed pressure (LVDP); maximum rise velocity (); maximum down velocity (); coronary flow (CF); heart rate (HR). and compared with control group; and compared with the I/R group.
