Indices of Paraoxonase and Oxidative Status Do Not Enhance the Prediction of Subclinical Cardiovascular Disease in Mixed-Ancestry South Africans

Table 4

Regression coefficients from multiple robust linear models for the prediction of CIMT by indices of PON1 and antioxidant status accounting for the potential effect of sex, age, diabetes, and adiposity.

	Age—sex—BMI		Diabetes		PON1		PONase		AREase		FRAP		TEAC		Ox-LDL		TBARS
	β	𝑃	β	𝑃	β	𝑃	β	𝑃	β	𝑃	β	𝑃	β	𝑃	β	𝑃	β	𝑃
Index	—	—	—	—	−0.0002	0.723	−0.00006	0.730	−0.0003	0.390	−0.00002	0.743	−0.00002	0.571	0.000004	0.539	0.00001	0.255
Age	0.009	<0.0001	0.008	<0.0001	0.008	<0.0001	0.008	<0.0001	0.008	<0. 0001	0.008	<0.0001	0.008	<0.0001	0.008	<0.0001	0.008	<0.0001
Sex (men)	0.151	<0.0001	0.150	<0.0001	0.149	<0.0001	0.150	<0.0001	0.141	<0.0001	0.151	<0.0001	0.150	<0.0001	0.145	<0.0001	0.145	<0.0001
BMI	0.004	0.002	0.003	0.017	0.003	0.029	0.003	0.030	0.003	0.041	0.003	0.030	0.003	0.035	0.003	0.027	0.003	0.043
Diabetes	—	—	0.124	<0.0001	0.122	<0.0001	0.121	<0.001	0.118	<0.0001	0.121	<0.0001	0.120	<0.0001	0.119	<0.0001	0.114	<0.0001
𝑅^2	0.264		0.292		0.292		0.293		0.291		0.295		0.293		0.292		0.294

BMI: body mass index; paraoxonase 1; PONase: paraoxonase; AREase: arylesterase; FRAP: ferric reducing ability of plasma; TEAC: trolox equivalent antioxidant capacity; Ox-LDL: oxidized LDL; TBARS: thiobarbituric acid reactive substances.