Dietary Lycium barbarum Polysaccharide Induces Nrf2/ARE Pathway and Ameliorates Insulin Resistance Induced by High-Fat via Activation of PI3K/AKT Signaling

Figure 2

LBP suppresses HFD-induced inflammation and regulates glucose metabolism in liver. (a) Western blot analyzed phospho-IRS-1, -PI3K, -AKT, -JNK1/2, and -GSK3β levels. Representative western blots are shown. (b) qRT-PCR analysis of MCP-1, IL-6, and TNF-α in liver of LBP-treated and untreated mice. Data was expressed as means ± SEM (𝑛=3 per group), ^##𝑃<0.01. (c) Glycogen concentrations of liver (mg/g liver). (d) Glucose production of liver (mmol/g protein). Data was expressed as means ± SEM (𝑛= 6–8 per group), ^#𝑃<0.05, ^##𝑃<0.01. (e) Representative periodic acid-schiff (PAS) staining on liver (400x).

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