Atorvastatin Represses the Angiotensin 2-Induced Oxidative Stress and Inflammatory Response in Dendritic Cells via the PI3K/Akt/Nrf 2 Pathway

Figure 2

Inhibitory effects of atorvastatin on Ang 2-induced BMDC maturation and inflammatory responses. After pretreatment with either PBS or Ang 2 (100 nM), BMDCs were exposed to various concentrations of atorvastatin (2.5, 5, or 10 μM) for 24 h. (a) Expression of the cell-surface markers CD40, CD83, CD80, and CD86, as determined by flow cytometry (𝑛=3). (b) Expression of cytokines in BMDCs analyzed by ELISA (𝑛=3). The data are shown as the mean ± (SD) (𝑛=3); ^∗𝑃<0.05 versus control; ^#𝑃<0.05 versus Ang 2 group.

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