Decitabine and SAHA-Induced Apoptosis Is Accompanied by Survivin Downregulation and Potentiated by ATRA in p53-Deficient Cells
(a) Viability, subG1 cell fraction, and ROS production in control cells and after 48 h ATRA, DAC + SAHA or DAC + SAHA + ATRA treatment of CML-T1 leukemic cell line. Error bars represent ±SEM of at least three measurements. (b) Fragmentation of PARP, expression of tumor suppressor p53, and proteins related to apoptosis monitored in CML-T1 cells by immunoblotting. Images are representatives of three experiments with similar results.