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Oxidative Medicine and Cellular Longevity
Volume 2014 (2014), Article ID 191624, 8 pages
http://dx.doi.org/10.1155/2014/191624
Research Article

The Protective Effects of Curcumin on Experimental Acute Liver Lesion Induced by Intestinal Ischemia-Reperfusion through Inhibiting the Pathway of NF-κB in a Rat Model

1Department of General Surgery, The Third People’s Hospital of Dalian, Dalian 116033, China
2Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian 116023, China
3Department of Pharmacology, Dalian Medical University, Dalian 116044, China
4Department of General Surgery, Liaoning Cancer Hospital and Institute, Shenyang 110042, China
5Department of General Surgery, Children’s Hospital of Dalian, Dalian 116000, China

Received 3 June 2014; Revised 29 July 2014; Accepted 1 August 2014; Published 20 August 2014

Academic Editor: Felipe Dal-Pizzol

Copyright © 2014 Zhe Fan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. In this study, we investigated the protective effect and mechanism of curcumin on a rat model of intestinal ischemia/reperfusion (I/R), which induces an acute liver lesion. Methods. Curcumin was injected into rats in the curcumin groups through left femoral vein. The same volume of vehicle (0.9% normal saline) was injected into sham and I/R groups. Blood and liver tissue were gathered for serological and histopathological determination. Results. Intestinal I/R led to severe liver injury manifested as a significant increase in serum AST and ALT levels; all of those were reduced by treatment with curcumin. Simultaneously, the activity of SOD in liver decreased after intestinal I/R, which was increased by curcumin treatment. On the other hand, curcumin reduced MPO activity of liver tissue, as well as serum IL-6 and TNF-α levels observably. This is in parallel with the decreased level of liver intercellular cell adhesion molecule-1 (ICAM-1) and nuclear factor-κB (NF-κB) expression. Conclusion. Our findings suggest that curcumin treatment attenuates liver lesion induced by intestinal I/R, attributable to the antioxidative and anti-inflammatory effect via inhibition of the NF-κB pathway.