Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS
Figure 2
Effect of a single oral 3 g dose of paracetamol on systemic prostacyclin and thromboxane synthesis and on renal synthesis of PGE2 in four healthy volunteers (time zero and baseline values are indicated by dashed arrows). (a) Creatinine-corrected urinary excretion of 2,3-dinor-6-keto-prostaglandin F1α (2,3-dn-6k-PGF1α) as a measure of systemic PGI2 synthesis. (b) Creatinine-corrected urinary excretion of 2,3-dinor-thromboxane B2 (2,3-dn-TxB2) as a measure of systemic TxA2 synthesis. (c) PGI2/TxA2 molar ratio calculated from the 2,3-dn-6k-PGF1α and 2,3-dn-TxB2 excretion rates shown in (a) and (b), respectively. (d) Creatinine-corrected urinary excretion of PGE2 as a measure of renal PGE2 synthesis. An asterisk in (a) indicates statistical significance () compared to basal values. Data are shown as mean ± SEM.
