Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS
Figure 3
Effect of a 3 g single oral dose of paracetamol on oxidative stress in four healthy volunteers (time zero and baseline value are indicated by dashed arrows). (a) Plasma total homocysteine (hCys) concentration and (b) creatinine-corrected urinary excretion rate of 15(S)-8-iso-prostaglandin F2α (15()-8-iso-PGF2α) as a measure of oxidative stress. Data are shown as mean ± SEM.
