Ghrelin Therapy Improves Survival after Whole-Body Ionizing Irradiation or Combined with Burn or Wound: Amelioration of Leukocytopenia, Thrombocytopenia, Splenomegaly, and Bone Marrow Injury

Figure 4

Ghrelin improved survival, body weight, and wound healing after whole-body ionizing irradiation combined with skin wound. = 10-11 per group; experiment was repeated once. For panel (a): survival versus R-W CI + Veh; versus RI + Veh, RI + Ghrelin, and R-W CI + Veh. For panel (b): wound closure versus R-W CI + Veh. For panel (c): body weight, versus R-W CI + Veh. For panel (d): each vehicle-treated nonirradiated mouse normally drank 3.64 ± 0.19 mL/day. Water consumption between vehicle and ghrelin treatments showed no difference. Veh: vehicle; RI: 9.5 Gy; R-W CI: 9.5 Gy and skin wound.

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