Oxidative Medicine and Cellular Longevity

Research Article

Resveratrol Counteracts Inflammation in Human M1 and M2 Macrophages upon Challenge with 7-Oxo-Cholesterol: Potential Therapeutic Implications in Atherosclerosis

Table 1

Flow cytometric analysis of differentiation and activation surface markers on M1 and M2 macrophage subsets.
Surface markersCtrLPS7oxo-CResveratrolResveratrol + 7oxo-C value
M1
CD14% NS
MFI NS
CD16% NS
MFI <0.05 
<0.001
CD163% NS
MFI NS
HLA-DR% NS
MFI <0.05
M2
CD14% NS
MFI <0.001
CD16% NS
MFI NS
CD163% NS
MFI NS
HLA-DR% NS
MFI NS
Results are expressed as percentage of positive cells (%) and mean fluorescence intensity (MFI) (mean ± SD; ). values were calculated by one-way ANOVA with a Bonferroni post hoc test. 7oxo-C: 7-oxo-cholesterol; NS: no significance. CD16 MFI: ctr M1 versus ctr M2, ; CD163 %: ctr M1 versus ctr M2, .
: indicate the statistical significant difference between numbers with the same symbol.