The Role of Nrf2-Mediated Pathway in Cardiac Remodeling and Heart Failure
Figure 2
Nrf2 protects against maladaptive cardiac responses to hemodynamic stress. (a) The left panel shows representative pictures of hearts of wild-type (WT) and Nrf2−/− mice after TAC. The right panel shows the heart weight/body weight (HW/BW) ratio. (b) Left ventricle fractional shortening (FS) (%) of WT and Nrf2−/− mice 2 weeks after TAC. (c) Representative confocal microscopic images of LV 4-HNE staining. 4-HNE-positive staining is shown in red. Nuclei are shown in blue (×630). Nrf2 gain- and loss-of-function on hypertrophic factor-induced ROS production in rat neonatal cardiomyocytes. Representative images and quantitative analysis of intracellular ROS production in norepinephrine (NE, 200 mol/L) or phenylephrine (PE, 100 mol/L) treated cardiac myocytes that were infected with adenovirus of Nrf2 (d) or rat Nrf2 shRNA (e). or versus control ad-Gal- or ad-Nrf2-infected cells that were treated with vehicles. The combined figures here were collected by the authors from different figures published in the study by Li et al. [7].
