Figure 1: Criteria of therapeutic effects and wound size determination. Panel (a) (A) Grade 0: no change or worse than before. (B) Grade 1: wound size reducing less than 1/2. (C) Grade 2: wound size reducing more than 1/2, the secretion obviously less than before, there is little necrosis, fresh granulation generated. (D) Grade 3: wound healing, completely epithelialized. Panel (b) Ulcer areas were calculated from film transparency tracings using grid paper.