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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 273475, 8 pages
http://dx.doi.org/10.1155/2014/273475
Clinical Study

Increased Growth Factors Play a Role in Wound Healing Promoted by Noninvasive Oxygen-Ozone Therapy in Diabetic Patients with Foot Ulcers

Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China

Received 14 March 2014; Revised 25 April 2014; Accepted 27 May 2014; Published 24 June 2014

Academic Editor: Ersin Fadillioglu

Copyright © 2014 Jing Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. J. Boulton, L. Vileikyte, G. Ragnarson-Tennvall, and J. Apelqvist, “The global burden of diabetic foot disease,” The Lancet, vol. 366, no. 9498, pp. 1719–1724, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. J. R. Wilcox, M. J. Carter, and S. Covington, “Frequency of debridements and time to heal: a retrospective cohort study of 312 744 wounds,” JAMA Dermatology, vol. 149, no. 9, pp. 1050–1058, 2013. View at Publisher · View at Google Scholar
  3. V. Bocci, E. Borrelli, V. Travagli, and I. Zanardi, “The ozone paradox: ozone is a strong oxidant as well as a medical drug,” Medicinal Research Reviews, vol. 29, no. 4, pp. 646–682, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. V. Travagli, I. Zanardi, and V. Bocci, “Topical applications of ozone and ozonated oils as anti-infective agents: an insight into the patent claims,” Recent Patents on Anti-Infective Drug Discovery, vol. 4, no. 2, pp. 130–142, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. Z. B. Zamora Rodríguez, R. González Álvarez, D. Guanche et al., “Antioxidant mechanism is involved in the gastroprotective effects of ozonized sunflower oil in ethanol-induced ulcers in rats,” Mediators of Inflammation, vol. 2007, Article ID 65873, 7 pages, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Agrillo, F. Filiaci, V. Ramieri et al., “Bisphosphonate-related osteonecrosis of the jaw (BRONJ): 5 year experience in the treatment of 131 cases with ozone therapy,” European Review for Medical and Pharmacological Sciences, vol. 16, no. 12, pp. 1741–1747, 2012. View at Google Scholar · View at Scopus
  7. G. Martínez-Sánchez, S. M. Al-Dalain, S. Menéndez et al., “Therapeutic efficacy of ozone in patients with diabetic foot,” European Journal of Pharmacology, vol. 523, pp. 151–161, 2005. View at Publisher · View at Google Scholar
  8. D. L. Steed, “Debridement,” The American Journal of Surgery, vol. 187, no. 5, supplement 1, pp. 71S–74S, 2004. View at Publisher · View at Google Scholar
  9. Y. Liu, D. Min, T. Bolton et al., “Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers,” Diabetes Care, vol. 32, no. 1, pp. 117–119, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Wainstein, Z. Feldbrin, M. Boaz, and I. Harman-Boehm, “Efficacy of ozone-oxygen therapy for the treatment of diabetic foot ulcers,” Diabetes Technology and Therapeutics, vol. 13, no. 12, pp. 1255–1260, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. S. M. Al-Dalain, G. Martínez, E. Candelario-Jalil et al., “Ozone treatment reduces markers of oxidative and endothelial damage in an experimental diabetes model in rats,” Pharmacological Research, vol. 44, no. 5, pp. 391–396, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Martínez, S. M. Al-Dalain, S. Menéndez, A. Giuliani, and O. S. León, “Ozone treatment reduces blood oxidative stress and pancreas damage in streptozotocin induced diabetes model in rats,” Acta Farmacéutica Bonaerense, vol. 24, pp. 491–497, 2005. View at Google Scholar
  13. L. Delgado-Roche, G. Martínez-Sánchez, and L. Re, “Ozone oxidative preconditioning prevents atherosclerosis development in New Zealand white rabbits,” Journal of Cardiovascular Pharmacology, vol. 61, no. 2, pp. 160–165, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. N. I. Shehata, H. M. Abd-Elgawad, M. N. Mawsouf, and A. A.-E. Shaheen, “The potential role of ozone in ameliorating the age-related biochemical changes in male rat cerebral cortex,” Biogerontology, vol. 13, no. 6, pp. 565–581, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Martínez-Sánchez, L. Delgado-Roche, A. Díaz-Batista, G. Pérez-Davison, and L. Re, “Effects of ozone therapy on haemostatic and oxidative stress index in coronary artery disease,” European Journal of Pharmacology, vol. 691, no. 1–3, pp. 156–162, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Martínez-Sánchez, S. M. Al-Dalain, S. Menéndez et al., “Therapeutic efficacy of ozone in patients with diabetic foot,” European Journal of Pharmacology, vol. 523, pp. 151–161, 2005. View at Publisher · View at Google Scholar
  17. E. B. Jude, R. Blakytny, J. Bulmer, A. J. M. Boulton, and M. W. J. Ferguson, “Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers,” Diabetic Medicine, vol. 19, no. 6, pp. 440–447, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Galkowska, U. Wojewodzka, and W. L. Olszewski, “Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers,” Wound Repair and Regeneration, vol. 14, no. 5, pp. 558–565, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. J. R. Hanft, R. A. Pollak, A. Barbul et al., “Phase I trial on the safety of topical rhVEGF on chronic neuropathic diabetic foot ulcers,” Journal of Wound Care, vol. 17, no. 1, pp. 30–37, 2008. View at Google Scholar · View at Scopus
  20. P. Losi, E. Briganti, C. Errico et al., “Fibrin-based scaffold incorporating VEGF- and bFGF-loaded nanoparticles stimulates wound healing in diabetic mice,” Acta Biomaterialia, vol. 9, no. 8, pp. 7814–7821, 2013. View at Publisher · View at Google Scholar · View at Scopus