Melatonin Therapy Prevents Programmed Hypertension and Nitric Oxide Deficiency in Offspring Exposed to Maternal Caloric Restriction

Figure 2

Representative western blots (a) showing protein arginine methyltransferase 1 (PRMT-1; ∼42 kDa), dimethylarginine dimethylaminohydrolase 1 (DDAH-1; ∼34 kDa), and DDAH-2 (∼30 kDa) bands in CR offspring at 12 weeks of age. Relative abundance of renal cortical (b) PRMT-1, (c) DDAH-1, and (d) DDAH-2. (e) Effect of melatonin and CR on renal DDAH activity in male offspring at 12 weeks of age. ^∗𝑃<0.05 versus control; ^#𝑃<0.05 versus CR.

(a)

(b)

(c)

(d)

(e)