Melatonin Therapy Prevents Programmed Hypertension and Nitric Oxide Deficiency in Offspring Exposed to Maternal Caloric Restriction

Table 2

Morphological and biochemical values in different experimental groups.

	Control	CR	M	CR + M
	𝑛=8	𝑛=8	𝑛=10	𝑛=8
Mortality	10%	0%	0%	0%
Body weight (BW) (g)	435 ± 14	356 ± 4*	489±8^∗#	370±9^∗$
Left kidney weight (g)	1.22 ± 0.06	1.01 ± 0.02	1.97 ± 0.05^*#	1.48 ± 0.03^#$
Left kidney weight/100g BW	0.28 ± 0.01	0.28 ± 0.01	0.4 ± 0.01^*#	0.4 ± 0.01^*#
Heart weight (g)	1.23 ± 0.05	1.24 ± 0.02	1.63 ± 0.01^*#	1.16 ± 0.05^$
Heart weight/100 g BW	0.28 ± 0.01	0.35 ± 0.01*	0.35 ± 0.01*	0.31 ± 0.01
Systolic blood pressure (mmHg)	162 ± 2	180 ± 2*	155 ± 1^#	166 ± 1^$
Diastolic blood pressure (mmHg)	122 ± 2	134 ± 3*	108 ± 2^*#	113 ± 1^*#
Mean arterial pressure (mmHg)	135 ± 2	149 ± 2*	124 ± 1^*#	131 ± 1^#$
CCr, mL·min^−1·kg body weight^−1	9.12 ± 3.45	8.5 ± 3.0	7.34 ± 2.32	7.81 ± 2.76

CCr: clearance of creatinine; ^∗𝑃<0.05 versus control; ^#𝑃<0.05 versus CR; ^$𝑃<0.05 versus M.