Melatonin Therapy Prevents Programmed Hypertension and Nitric Oxide Deficiency in Offspring Exposed to Maternal Caloric Restriction

Table 3

L-Citrulline, L-arginine, and dimethylarginine levels in the plasma and kidney.

	Control	CR	M	CR + M
Plasma (μmol)
L-Citrulline	50 ± 4.1	61 ± 3.6	59.3 ± 5.1	55.8 ± 6.9
L-Arginine	121.1 ± 14	84.4 ± 2.4*	113.6 ± 8.7^#	112.8 ± 13.6^#
ADMA	1.31 ± 0.1	2.21 ± 0.18*	1.18 ± 0.06^#	1.08 ± 0.12^#
SDMA	0.66 ± 0.04	1.62 ± 0.27*	0.97 ± 0.09^#	0.92 ± 0.08^#
L-Arginine-to-ADMA ratio	92 ± 8	40 ± 4*	98 ± 10^#	105 ± 6^#
Kidney (μmol/mg protein)
L-Citrulline	52.5 ± 8.6	53.1 ± 4.6	97.6 ± 8.4	68.8 ± 12.4
L-Arginine	425 ± 62.3	552.9 ± 58.9	522.8 ± 61.6	488.1 ± 56
ADMA	5.09 ± 0.88	6.33 ± 0.71	6.72 ± 1.03	4.84 ± 0.61
SDMA	4.3 ± 0.65	5.3 ± 0.51	5.57 ± 0.79	4.59 ± 0.73
L-Arginine-to-ADMA ratio	86 ± 4	89 ± 5	80 ± 4	103 ± 8^$

^∗𝑃<0.05 versus control; ^#𝑃<0.05 versus CR; ^$𝑃<0.05 versus M.