Enhancement of Cellular Antioxidant-Defence Preserves Diastolic Dysfunction via Regulation of Both Diastolic Zn2+ and Ca2+ and Prevention of RyR2-Leak in Hyperglycemic Cardiomyocytes
Figure 1
Body weight, blood glucose, and oxidative stress markers of normal rats (CON group) and diabetic (DM) rats treated with N-acetyl cysteine (DM + NAC group) or untreated DM rats. (a) Body weight (left) and blood glucose levels (right) in the rats both at the beginning (first column) and 5th week end (second column) of experimental period. (b) The levels of lipid peroxidation marker malondialdehyde, MDA, (left) and the reduced glutathione to oxidized glutathione (GSH/GSSG) ratio (right), and (c) total (right) and free (left) thiol (SH) levels measured in heart homogenates. Bar graphs represent mean ± SEM values and number of rats in groups; , , and , respectively. Significant at *, due to comparison between 1st and 5th weeks.
