Enhancement of Cellular Antioxidant-Defence Preserves Diastolic Dysfunction via Regulation of Both Diastolic Zn2+ and Ca2+ and Prevention of RyR2-Leak in Hyperglycemic Cardiomyocytes
Figure 2
Morphological findings in experimental rat hearts. Micrographs of left ventricular cross section through control (CON), diabetic (DM), and N-acetyl cysteine (NAC)-treated diabetic (DM + NAC group; 150 mg/kg, daily and intragastrically, for 4 weeks) groups, respectively, obtained by electron microscopy. (a) There is no sign of any tissue necrosis in CON group. Marked alterations in myofilaments and sarcoplasmic reticulum (SR), destruction in Z-lines (Z), loss of cristae and granular matrix in mitochondria (M), and also increased numbers of lipid droplets (L) are seen in DM group (b) while these alterations have almost disappeared with NAC treatment (c); magnifications are ×12,390, ×10,000, and ×12,990 for (a), (b), and (c), respectively.
