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Oxidative Medicine and Cellular Longevity
Volume 2014 (2014), Article ID 293689, 12 pages
http://dx.doi.org/10.1155/2014/293689
Review Article

Oxidative Stress Associated with Neuronal Apoptosis in Experimental Models of Epilepsy

1Laboratorio de Neuropatología Experimental, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Insurgentes Sur 3877, La Fama, CP 14269, Tlalpan, DF, Mexico
2Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Avenida Universidad 3000, CP 04510, Coyoacán, DF, Mexico
3Departamento de Genética, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Insurgentes Sur 3877, CP 14269, La Fama, Tlalpan, DF, Mexico

Received 14 March 2014; Accepted 7 August 2014; Published 29 December 2014

Academic Editor: Xiaotao Li

Copyright © 2014 Marisela Méndez-Armenta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Epilepsy is considered one of the most common neurological disorders worldwide. Oxidative stress produced by free radicals may play a role in the initiation and progression of epilepsy; the changes in the mitochondrial and the oxidative stress state can lead mechanism associated with neuronal death pathway. Bioenergetics state failure and impaired mitochondrial function include excessive free radical production with impaired synthesis of antioxidants. This review summarizes evidence that suggest what is the role of oxidative stress on induction of apoptosis in experimental models of epilepsy.