Anticonvulsant and Antioxidant Effects of Tilia americana var. mexicana and Flavonoids Constituents in the Pentylenetetrazole-Induced Seizures

Table 1

Anticonvulsive effects of some flavonoids in the pentylenetetrazole-induced seizures in mice.

Treatment	Dose (mg/kg, i.p.)	Latency to the onset (min) and percentage of mice showing seizure
		Myoclonus		Tonic-clonic		Tonic
Vehicle	0	0.82 ± 0.12	100%	1.41 ± 0.27	100%	11.14 ± 1.15	100%
Quercetin	100	1.22 ± 0.23	100%	1.40 ± 0.24	100%	12.12 ± 2.21	100%
Rutin	30	1.25 ± 0.21	100%	2.46 ± 0.82	100%	21.83 ± 4.80*	33%
Isoquercitrin	10	0.80 ± 0.07	100%	1.04 ± 0.11	100%	23.87 ± 4.11*	33%

Data are represented as the mean ± SE of three independent assays. *, ANOVA followed by Tukey’s test.