Early Onset Alzheimer’s Disease and Oxidative Stress

Figure 1

APPβ processing. the APP is an integral membrane protein and is sequentially processed by the three proteases α-, β-, and γ-secretase. The nonamyloidogenic pathway involves the α-secretase, which made the cut at the middle portion of the fragment corresponding to the amyloid sequence, preventing the amyloid peptides generation. The amyloidogenic pathway involves β-secretase, leading to the formation of C-terminal fragments (CTFs) that are subsequently cleaved by the “γ-secretase-complex” which is responsible for the formation of Aβ (40 or 42 amino acids in length) and the AβPP intracellular domain peptide (AICD) of 58 or 56 amino acids.