Aging was associated with increased ROS (MDA and MPO) and decreased reduced glutathione (GSH) after nitrates use. (a) Plasma malondialdehyde (MDA) concentration was higher in old patients than in adult patients; (b) plasma-reduced glutathione (GSH) concentration was lower in old patients than in adult patients; and (c) plasma myeloperoxidase (MPO) concentration was greater in elderly than adult patients. (d), (e), and (f) indicated aging was associated with increased ROS (MDA and MPO) and decreased reduced GSH in rat cardiac tissue after 12 hours nitrates use. Adult indicates adult group, and elderly indicates elderly group. Totals for the following groups: 32 adult patients; 43 elderly patients. Sham indicates sham group; young and old indicate rats receiving nitrates treatment. In animal experiment, per group. Data are expressed as mean ± SEM. versus adult group. per group. Data are expressed as mean ± SEM. , versus young group.
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