The effects of aging on nitrates-induced NOx and nitrotyrosine content change in patients plasma and rats cardiac tissue. (a) indicated the effects of aging on patients plasma NOx content; (b) rats cardiac tissue NOx content; (c) patients plasma nitrotyrosine concentration; and (d) rats cardiac tissue nitrotyrosine concentration. Nitrates were used in patients for 48 h and in rats for 12 h. Sham indicates sham group; young and old indicate rats receiving nitrates treatment. 32 adult patients and 43 elderly patients were included in the trial. In animal experiment, per group. Data are expressed as mean ± SEM. versus young/adult group.
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