The Potential Protective Effect of Physalis peruviana L. against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Is Mediated by Suppression of Oxidative Stress and Downregulation of MMP-9 Expression

Table 3

Sera MDA, NO, and GSH and hepatic MDA, NO, GSH, GRd, GST, and GPx in different studied groups.

Parameters	Group I	Group II	Group III	Group IV
Serum MDA (nmol/mL)	32.37±0.61	50.21±1.46^a	23.18±1.51^a	37.52±1.38^b
Serum NO (𝜇mol/L)	47.33±1.64	101.13±4.79^a	52.30±2.99	80.10±2.10^ab
Serum GSH (mmol/mL)	53.02±2.86	39.13±1.31^a	72.00±4.91^a	63.46±3.65^ab
Hepatic MDA (nmol/g tissue)	427.19±4.79	591.45±12.47^a	360.75±7.85^a	406.82±2.80^b
Hepatic NO (μmol/g tissue)	128.54±2.39	226.50±2.93^a	139.33±6.82	184.59±8.67^ab
Liver GSH (mmol/g tissue)	36.69±2.01	25.09±1.47^a	55.51±2.73^a	44.16±5.66^b
Hepatic GRd (𝜇mol/g tissue)	102.48±8.97	41.5297±3.15^a	105.16±10.95	86.4085±5.75^b
Hepatic GST (𝜇mol/h/g tissue)	0.27±0.03	0.12±0.01^a	0.31±0.02	0.22±0.03^ab
Hepatic GPx (U/g tissue)	1722.43±69.21	616.02±27.76^a	2054.37±54.68^a	1532.68±38.97^b

Values are means ± SEM (𝑛=7).
^a𝑃<0.05, significant change with respect to Group I; ^b𝑃<0.05, significant change with respect to Group II.