Flutamide-Induced Cytotoxicity and Oxidative Stress in an In Vitro Rat Hepatocyte System

Figure 4

Effects of nontoxic H₂O₂ and peroxidase or Fe(II)-mediated Fenton model on FLU-induced cytotoxicity. Data are presented as mean ± SEM (). Refer to the Materials and Methods section for the description of the experiments performed and experimental conditions. HRP: horseradish peroxidase; G: glucose; GO: glucose oxidase; PTU: 6-N-propyl-2-thiouracil. ^aSignificant compared to control hepatocytes; ^bsignificant compared to 75 µM FLU; ^csignificant compared to 75 µM FLU + G + GO + HRP; ^dsignificant compared to 75 µM FLU + G + GO + Fe(II)-mediated Fenton model.