Research Article
Flutamide-Induced Cytotoxicity and Oxidative Stress in an In Vitro Rat Hepatocyte System
Table 1
FLU-induced cytotoxicity and oxidative stress using an in vitro oxidative stress inflammation system in isolated rat hepatocytes.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Data are presented as mean ± SEM (). Refer to the Materials and Methods section for a description of the experiments performed and experimental conditions. LPO: lipid peroxidation; MMP: mitochondrial membrane potential; HRP: horseradish peroxidase; PTU: 6-N-propyl-2-thiouracil; NAC: N-acetylcysteine; Trolox: (±)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; resveratrol: 3,5,4′-trihydroxy-trans-stilbene; TEMPOL: 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl; DPPD: N,N′-diphenyl-p-phenylenediamine. Significant compared to control (only hepatocytes). Significant compared to 75 µM FLU. Significant compared to 75 µM FLU + H2O2 generating system + HRP. |