Aging Leads to Elevation of O-GlcNAcylation and Disruption of Mitochondrial Homeostasis in Retina

Figure 1

Mitochondrial biogenesis status in retinas of young and old rats. SD rats aged five months (young) and 25 months (old) were sacrificed; total proteins of retina tissues were prepared for analysis. Mitochondrial complexes expressions including Complexes I, II, III, IV, and V were detected by Western blot ((a) Western blot image and (b) statistical analysis). Mitochondrial biogenesis regulators, PGC-1α and mtTFA, were analyzed by Western blot ((c) Western blot image and (d) statistical analysis). The values are the means ± S.E.M from 8 rats per group. ^∗𝑃<0.05 and ^∗∗𝑃<0.01 as calculated by Student’s 𝑡-test.

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