A Novel Contrast-Induced Acute Kidney Injury Model Based on the 5/6-Nephrectomy Rat and Nephrotoxicological Evaluation of Iohexol and Iodixanol In Vivo

Figure 3

A marked reduction in renal function was induced by dehydration for 48 hours before iodixanol administration in 5/6 NE rats. (a) BP levels were not different among the six groups before saline or ICM injection. Changes in the levels of (b) Scr, (c) BUN, and (d) Ccr before and after an intravenous injection of iodixanol or saline. Animals showed marked deterioration of renal function 24 hours after iodixanol injections in the 48 h dehydration + iodixanol group. In the saline group, the 48 h dehydration + saline group, the iodixanol group, the 24 h dehydration + iodixanol group, and the 48 h dehydration + low dose iodixanol group, there were no statistical changes of renal function between baseline and final levels (Figures 2(b)–2(d)). and end point versus baseline in every group; .

(a)

(b)

(c)

(d)