Lack of Association between Nuclear Factor Erythroid-Derived 2-Like 2 Promoter Gene Polymorphisms and Oxidative Stress Biomarkers in Amyotrophic Lateral Sclerosis Patients

Table 1

Distributions of genotypes and allele frequencies in SNP −653 A/G in ALS patients and in controls.

	ALS patients	Controls	𝜒^2 test	𝑃 value
Genotypes −653 A/G	𝑁: 145	𝑁: 168
AA	71 (49%)	95 (56.5%)	—	—
AG	66 (45.5%)	62 (37%)	—	—
GG	8 (5.5%)	11 (6.5%)	—	—
AG + GG	74 (51%)	73 (43.4%)	1.8	0.18
Allele G frequency			0.8	0.36
Males	𝑁: 88	𝑁: 84
AA	41 (46.7%)	44 (52.3%)	—	—
AG	45 (51.1%)	34 (40.5%)	—	—
GG	2 (2.2%)	6 (7.2%)	—	—
AG + GG	47 (53.3%)	40 (42.7%)	0.57	0.44
Allele G frequency			0.009	0.92
Females	𝑁: 57	𝑁: 84
AA	30 (52.6%)	51 (60.7%)	—	—
AG	21 (36.8%)	28 (33.3%)	—	—
GG	6 (10.5%)	5 (6%)	—	—
AG + GG	27 (47.4%)	33 (39.3%)	0.9	0.34
Allele G frequency			1.5	0.21