Lack of Association between Nuclear Factor Erythroid-Derived 2-Like 2 Promoter Gene Polymorphisms and Oxidative Stress Biomarkers in Amyotrophic Lateral Sclerosis Patients

Table 2

Distributions of genotypes and allele frequencies in SNP −651 G/A in ALS patients and in controls.

	sALS patients	Controls	𝜒^2 test	𝑃 value
Genotypes −651 G/A	𝑁: 145	𝑁: 168
GG	105 (72.4%)	130 (77.4%)	—	—
GA	40 (27.6%)	35 (20.9%)	—	—
AA	0	3 (1.7%)	—	—
GA + AA	40 (27.6%)	38 (22.6%)	1.02	0.31
Allele A frequency			0.35	0.55
Males	𝑁: 88	𝑁: 84
GG	66 (75%)	68 (80.9%)	—	—
GA	22 (25%)	16 (19.1%)	—	—
AA	0	0	—	—
GA + AA	22 (25%)	16 (19.1%)	0.88	0.34
Allele A frequency			0.77	0.37
Females	𝑁: 57	𝑁: 84
GG	39 (68.4%)	62 (74%)	—	—
GA	18 (31.6%)	19 (22.4%)	—	—
AA	0	3 (3.6%)	—	—
GA + AA	18 (31.6%)	22 (26.2%)	0.48	0.47
Allele A frequency			0.95	0.32