Lack of Association between Nuclear Factor Erythroid-Derived 2-Like 2 Promoter Gene Polymorphisms and Oxidative Stress Biomarkers in Amyotrophic Lateral Sclerosis Patients

Table 3

Distributions of genotypes and allele frequencies in SNP −617 C/A in ALS patients and in controls.

	sALS patients	Controls	𝜒^2 test	𝑃 value
Genotypes −617 C/A	𝑁: 145	𝑁: 168
CC	109 (75.2%)	123 (73.2%)	—	—
CA	34 (23.4%)	41 (24.4%)	—	—
AA	2 (1.4%)	4 (2.4%)	—	—
CA + AA	36 (24.8%)	45 (26.8%)	0.09	0.7
Allele A frequency			0.28	0.59
Males	𝑁: 88	𝑁: 84
CC	62 (70.4%)	59 (70.3%)	—	—
CA	24 (27.3%)	21 (25%)	—	—
AA	2 (2.3%)	4 (4.7%)	—	—
CA + AA	26 (29.6%)	25 (29.7%)	0.001	0.98
Allele A frequency			0.09	0.75
Females	𝑁: 57	𝑁: 84
CC	47 (82.5%)	64 (76.2%)	—	—
CA	10 (17.5%)	20 (23.8%)	—	—
AA	0	0	—	—
CA + AA	10 (17.5%)	20 (23.8%)	0.5	0.47
Allele A frequency			0.7	0.4