Metallothionein-II Inhibits Lipid Peroxidation and Improves Functional Recovery after Transient Brain Ischemia and Reperfusion in Rats

<table>Lipid peroxidation 24 h after transient cerebral ischemia and reperfusion (I/R). Sham: rats without I/R; I/R: rats with 2 h of ischemia and 22 of reperfusion plus vehicle; I/R + MT-II: animals with 2 h of ischemia and 22 of reperfusion treated with MT-II (10 <i>μ</i>g/per rat) 30 min and 8 h after ischemia. (a) Lipid peroxidation in frontal cortex and (b) Lipid peroxidation in hippocampus. The results are expressed as means ± S.E.M. of 8–10 animals per group. *Different from both sham group and contralateral striatum (<svg height="11.375" id="M4" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>). One-way ANOVA followed by Dunnett’s test for between-groups comparison and paired-samples <svg height="10.3875" id="M5" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 5.9250002 10.3875" width="5.9250002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>-test for contralateral versus ipsilateral comparisons.</table>

Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Metallothionein-II Inhibits Lipid Peroxidation and Improves Functional Recovery after Transient Brain Ischemia and Reperfusion in Rats 