Metallothionein-II Inhibits Lipid Peroxidation and Improves Functional Recovery after Transient Brain Ischemia and Reperfusion in Rats
Figure 2
Neurological deficits evaluated after transient cerebral ischemia and reperfusion (I/R) at several times after administration of MT-II. Rats receiving 250 μL of saline solution as vehicle (I/R) or MT-II(I/R + MT-II) at a dose of 10 μg per rat via i.p. dissolved in 250 μL of saline solution. Both treatments were at 30 min and 8 hours after ischemia and neurological deficits were evaluated with Longa scale at 2, 24, 48, and 72 h. Results are expressed as the mean ± S.E.M. of scores of animals per group. * Different from control group, , repeated-measures ANOVA, followed by Dunnett’s test.
