Dietary Blueberry and Bifidobacteria Attenuate Nonalcoholic Fatty Liver Disease in Rats by Affecting SIRT1-Mediated Signaling Pathway

Figure 8

Effect of blueberry juice and bifidobacteria on protein expression of SIRT1, SREBP-1c, and PPAR-a in NAFLD rat livers. In control group (CG), the protein levels of SIRT1 and PPAR-α were high while the level of SREBP-1c was low. In NAFLD model group (MG) or model group with SIRT1 RNAi (SI), the protein levels of SIRT1 and PPAR-α were low while the level of SREBP-1c was high. In blueberry juice group (BJ), the protein levels of SIRT1 and PPAR-α were high while the level of SREBP-1c was low. In blueberry juice and SIRT1 RNAi group (BJSI), the protein levels of SIRT1 and PPAR-α were very low while the level of SREBP-1c was high. In blueberry juice and bifidobacteria group (BJB), the protein levels of SIRT1 and PPAR-α were high while the level of SREBP-1c was low. In blueberry juice and bifidobacteria and SIRT1 RNAi group (BJBSI), the protein levels of SIRT1 and PPAR-α were very low while the level of SREBP-1c was high. Error bars indicate SD (). versus the control group, ^# versus the model group.