Hemin Attenuates Cisplatin-Induced Acute Renal Injury in Male Rats
Table 1
The results of biochemical analysis in control and experimental groupsa.
Parameters
Unit
Control
CP
CP + hemin
Hemin
Urea
mg/dL
48.60 ± 1.50
151.61 ± 10.02b
86.61 ± 3.02b,c
53.60 ± 3.20c
Creatinine
mg/dL
0.81 ± 0.11
5.14 ± 0.76b
1.45 ± 0.69c
0.78 ± 0.08c
TBARS
nmole MDA/g tissue
6.44 ± 1.67
11.00 ± 1.05b
7.26 ± 2.74
4.06 ± 1.53c
NO
mole/g tissue
16.42 ± 0.98
19.58 ± 1.50b
13.16 ± 0.71b,c
11.86 ± 0.84b,c
NOS
nmole/g tissue
5.56 ± 0.84
25.61 ± 7.50b
16.34 ± 2.19
6.07 ± 0.89c
GPx
mU/mg protein
353.51 ± 44.43
238.49 ± 40.83b
311.15 ± 25.76
376.81 ± 30.18c
SOD
U/mg protein
18.14 ± 2.76
14.01 ± 1.85
17.59 ± 1.83
18.08 ± 1.15
GR
mU/mg protein
98.79 ± 8.40
67.63 ± 6.03b
86.26 ± 9.13
105.75 ± 10.73c
GSH
mole/mg protein
6.68 ± 1.10
6.93 ± 0.59
9.15 ± 1.01b
10.05 ± 0.37b,c
TBARS: thiobarbituric acid reactive substances, MDA: malondialdehyde, NO: nitric oxide, NOS: nitric oxide synthetase, GPx: glutathione peroxidase, SOD: superoxide dismutase, GR: Glutathione reductase, and GSH: reduced glutathione.
aResults are expressed as mean ± SE for six replicates.
bSignificantly different from control at < 0.05 by one-way ANOVA.
cSignificantly different from CP at < 0.05 by one-way ANOVA.