Pegylated G-CSF Inhibits Blood Cell Depletion, Increases Platelets, Blocks Splenomegaly, and Improves Survival after Whole-Body Ionizing Irradiation but Not after Irradiation Combined with Burn

Figure 1

Peg-G-CSF improved survival after whole-body ionizing irradiation alone but not after irradiation combined with skin burn. 𝑁=20--22 per group. For (a) ^∗𝑃<0.05 versus sham, burn, and CI; ^∗∗𝑃<0.05 versus sham burn and CI. For (b) ^∗𝑃=0.0033 RI + peg-G-CSF versus RI + Vehicle and RI. For (c) ^∗𝑃<0.05 versus CI. For (d) representing 100% survival in peg-G-CSF treated RI mice. RI: 9.5 Gy; CI: 9.5 Gy and skin burn.

(a) Control mice

(b) RI mice

(c) CI mice

(d) Vehicle versus peg-G-CSF