Pegylated G-CSF Inhibits Blood Cell Depletion, Increases Platelets, Blocks Splenomegaly, and Improves Survival after Whole-Body Ionizing Irradiation but Not after Irradiation Combined with Burn

<table class="table-group" width="800px"><tr class="fig-image" id="a"><td><img alt="481392.fig.004a" src="https://static.hindawi.com/articles/omcl/volume-2014/481392/figures/481392.fig.004a.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(a) </b>WBC</td></tr></table></td></tr><tr class="fig-image" id="b"><td><img alt="481392.fig.004b" src="https://static.hindawi.com/articles/omcl/volume-2014/481392/figures/481392.fig.004b.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(b) </b>Neutrophils</td></tr></table></td></tr><tr class="fig-image" id="c"><td><img alt="481392.fig.004c" src="https://static.hindawi.com/articles/omcl/volume-2014/481392/figures/481392.fig.004c.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(c) </b>Lymphocytes</td></tr></table></td></tr><tr class="fig-image" id="d"><td><img alt="481392.fig.004d" src="https://static.hindawi.com/articles/omcl/volume-2014/481392/figures/481392.fig.004d.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(d) </b>Monocytes</td></tr></table></td></tr></table>

<table>Peg-G-CSF mitigated WBC depletion after whole-body ionizing irradiation alone but not after irradiation combined with skin burn at day 30 after burn, RI, or CI. <svg height="11.375" id="M17" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 42.5625 11.375" width="42.5625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> per group. <svg height="13.95" id="M18" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus sham and burn; <svg height="15.775" id="M19" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 67.387497 15.775" width="67.387497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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<g transform="matrix(.017,-0,0,-.017,8.737,15.5)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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</svg> versus RI;  <svg height="15.0125" id="M20" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 69.150002 15.0125" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,2.9,6.587)"><path d="M574 0h-62l-217 479h-2l-217 -479h-62l249 548h62z" id="x2227"></path></g>
<g transform="matrix(.017,-0,0,-.017,10.5,14.738)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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</svg> versus RI + Vehicle. RI: 9.5 Gy; CI: 9.5 Gy and skin burn.</table>

Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Pegylated G-CSF Inhibits Blood Cell Depletion, Increases Platelets, Blocks Splenomegaly, and Improves Survival after Whole-Body Ionizing Irradiation but Not after Irradiation Combined with Burn 

Figure 4 | Pegylated G-CSF Inhibits Blood Cell Depletion, Increases Platelets, Blocks Splenomegaly, and Improves Survival after Whole-Body Ionizing Irradiation but Not after Irradiation Combined with Burn 