Lipoxygenase Pathway Mediates Increases of Airway Resistance and Lung Inflation Induced by Exposure to Nanotitanium Dioxide in Rats

Figure 1

Changes in lung mechanics in rats induced by different doses of nanotitanium dioxide inhalation. After-inhalation significant increases in specific airway resistance (SRaw) and functional residual capacity (FRC) were observed; and significant decreases in peak expiratory flow (PEF) were noted. Lung parenchymal damage as represented by lactate dehydrogenase (LDH) level rose after-exposure (*𝑃<0.05; **𝑃<0.01; ***𝑃<0.001).