Lipoxygenase Pathway Mediates Increases of Airway Resistance and Lung Inflation Induced by Exposure to Nanotitanium Dioxide in Rats

Figure 2

Kinetic changes in leukotriene C4 concentration in bronchoalveolar lavage fluid (BALF) after nanotitanium dioxide inhalation. The peak leukotriene C4 level was observed 8 hr after-exposure. Therefore, in all subsequent experiments, measurements were taken at 8 hr after-exposure (*𝑃<0.05; **𝑃<0.01; ***𝑃<0.001).