Research Article
Lipoxygenase Pathway Mediates Increases of Airway Resistance and Lung Inflation Induced by Exposure to Nanotitanium Dioxide in Rats
Figure 3
Aerosolized nanoparticles of titanium dioxide (4 mg/kg) induced significant increase of specific airway resistance (SRaw), significant decrease of peak expiratory flow rate (PEF), and the effects of leukotriene receptor antagonist (MK571) and leukotriene synthase inhibitor (MK886) before-treatment. (**; ***; ++; +++. * denotes comparison before- and after-exposure; + denotes comparison with nanoexposure control.)