Research Article
Lipoxygenase Pathway Mediates Increases of Airway Resistance and Lung Inflation Induced by Exposure to Nanotitanium Dioxide in Rats
Figure 7
Aerosolized nanoparticles of titanium dioxide (4 mg/kg) induced significant rise of nitric oxide (NO) in blood (a) and bronchoalveolar lavage fluid (BALF) (b) and the effects of leukotriene receptor antagonist (MK571) and leukotriene synthase inhibitor (MK886) before-treatment. (**; ***; +; +++. * denotes comparison before- and after-exposure; + denotes comparison with nanoexposure control.)