Lipoxygenase Pathway Mediates Increases of Airway Resistance and Lung Inflation Induced by Exposure to Nanotitanium Dioxide in Rats

Figure 8

Aerosolized nanoparticles of titanium dioxide (4 mg/kg) induced significant oxygen radical release by WBC in blood (H₂O₂/WBC) (a) and bronchoalveolar lavage fluid (BALF) represented by methylguanidine (MG) (b) and the effects of leukotriene receptor antagonist (MK571) and leukotriene synthase inhibitor (MK886) before-treatment. (***𝑃<0.001; ⁺𝑃<0.05. * denotes comparison before- and after-exposure; + denotes comparison with nanoexposure control.)

(a)

(b)