Lipoxygenase Pathway Mediates Increases of Airway Resistance and Lung Inflation Induced by Exposure to Nanotitanium Dioxide in Rats

Figure 9

mRNA expressions of 5-lipoxygenase, iNOS, and eNOS after TiO₂ exposure. The results showed upregulation of 5-lipoxygenase and iNOS expressions and downregulation of eNOS expression in rat lung after TiO₂ exposure. nTiO₂ exposure also induced significant increases in IL6 and TNFα concentrations in BALF. (*𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001).

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