RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells

Figure 2

RCAN1 regulates mitochondrial morphology. Representative electron-micrographs from (a) wild-type and (b) RCAN1^ox chromaffin cells captured at 4000x magnification (scale bar = 300 nm). RCAN1^ox chromaffin cells (black bars) have (c) a greater density of mitochondria and (d) significantly smaller mitochondria when compared to wild-type controls (white bars). (e) RCAN1^ox cells (red line) have a higher frequency of smaller mitochondria when compared to wild-type controls (black line). 𝑛=9 cells from 3 animals for each genotype, error bars represent the SEM, ^∗𝑃<0.05, and ^∗∗𝑃<0.01.

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