Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies

Table 7

Miscellaneous pathologies displaying OS/MDF hallmarks.

Diseases/conditions	OS/MDF hallmarks	References
Cataract	↑ TBARS; ↓ thiols; ↓ ferric reducing/antioxidant power;	[284–288]
	↑ dehydroascorbate/ascorbate; ↑ G/G genotype of SOD-1—251A/G
	polymorphism; H2O2-specific induction of Prdx3 in the eye lens
Fibromyalgia	↑ lipid peroxidation; ↓ total antioxidant capacity; ↑ TNF-𝛼;	[289–293]
	↓ ΔΨ; ↓ CoQ10; ↑ mt ^•O2^−; excess mitophagy
Malformations	OS and MDF in teratogenic action; thalidomide causes embryonic DNA	[294–300]
	oxidation in susceptible but not resistant species; GSH depletion, or inhibition
	of GPx or GR; ↓ mt NADH oxidase in teratogen-sensitive embryonic tissues;
	ethanol upregulates NOX regulatory subunits and increases NOX expression;
	↓ complex I and IV and ATP synthase in fetal alcohol syndrome